PHD finger protein 20-like protein 1 (PHF20L1) is a 1017-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A8MW92.
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The mean pLDDT of this model is 54.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 62% |
What pLDDT means and how to read it
Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity)
Interacts with methylated DNMT1 (DNMT1K142me1) (PubMed:24492612). Interacts with SOX2 (PubMed:29358331)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6L1P | X-ray | 1.23 Å | A/B/C/D=5-70 |
| 6L0X | X-ray | 1.3 Å | A/B=5-70 |
| 6L1C | X-ray | 1.58 Å | A=5-70 |
| 6L10 | X-ray | 1.6 Å | A/B/C/D=5-70 |
| 6L1I | X-ray | 1.85 Å | B=5-70 |
| 6L1F | X-ray | 1.9 Å | B=5-70 |
| 2EQM | NMR | A=1-81 | |
| 2EQU | NMR | A=85-143 | |
| 2JTF | NMR | A=1-74 |
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