Major histocompatibility complex class I-related protein 1 (MR1) is a 336-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: C1ITJ8.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are…
Heterotrimer that consists of MR1, B2M and metabolite antigen (By similarity). Major classes of metabolite ligands presented by MR1 include riboflavin-related antigens, pyrimidines and ribityl lumazines, nucleobase adducts and folate derivatives. Forms reversible covalent Schiff base complexes with microbial pyrimidine-based metabolite, which serves as a molecular switch triggering complete…
Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Early endosome membrane, Late endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4IIQ | X-ray | 2.86 Å | C=19-295 |
| 4L8S | X-ray | 2.9 Å | C=19-295 |
| 4LCC | X-ray | 3.26 Å | C=19-295 |
| 4L9L | X-ray | 3.4 Å | C=19-295 |
| 7RNO | NMR | A=201-288 |
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