EF-hand domain-containing family member B (EFHB) is a 877-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: F1MMV1.
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The mean pLDDT of this model is 62.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity)
Microtubule inner protein component of sperm flagellar doublet microtubules (PubMed:37327785). Interacts with STIM1 and ORAI1; the interactions take place upon Ca(2+)-store depletion and dissociate through a Ca(2+)-dependent mechanism. Interaction with STIM1 inhibits STIM1 interaction with SARAF (By similarity)
Cytoplasm, cytoskeleton, cilium axoneme, Cytoplasm, cytoskeleton, flagellum axoneme, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RRO | EM | 3.4 Å | 1/2=1-877 |
| 9CPB | EM | 3.52 Å | 2D/2E=1-877 |
| 8OTZ | EM | 3.6 Å | E/F=1-877 |
| 9FQR | EM | 5.0 Å | E/F/On/Pu/n=1-877 |
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