Cilia- and flagella-associated protein 53 (CFAP53) is a 514-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: F1N7G5.
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The mean pLDDT of this model is 83.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for centriolar satellite integrity and non-motile cilium assembly (By similarity). Required for motile cilium formation (By similarity). Through its role in beating of primary cilia, involved in the establishment of organ laterality during embryogenesis (PubMed:34715025). Required for sperm flagellum biogenesis and is essential for male…
Microtubule inner protein component of sperm flagellar doublet microtubules (PubMed:37327785). Interacts with PIERCE1 and PIERCE2; the interactions link outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme (PubMed:34715025). Interacts with CCDC38 (By similarity). Interacts with CCDC42 and IFT88 (By similarity). Interacts with centriolar…
Cytoplasm, cytoskeleton, cilium axoneme, Cytoplasm, cytoskeleton, flagellum axoneme, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite, Cytoplasm, cytoskeleton, spindle pole, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RRO | EM | 3.4 Å | 3/4=1-514 |
| 9CPB | EM | 3.52 Å | 2S/2T=1-514 |
| 8OTZ | EM | 3.6 Å | AT/AU=1-514 |
| 9FQR | EM | 5.0 Å | AU/Af/Ag/Kc=1-514 |
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