I3LCH3: DNA-directed RNA polymerase II subunit RPB3 (POLR2C)

DNA-directed RNA polymerase II subunit RPB3 (POLR2C) is a 275-residue protein from Sus scrofa. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: I3LCH3.

Gene: POLR2C
Organism: Sus scrofa
Length: 275 residues
Mean pLDDT: 90.2
Model: AF-I3LCH3-F1 v6
Model created: 1 Jun 2022
PDB structures: 107

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Model confidence (pLDDT)

The mean pLDDT of this model is 90.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	76%
70 to 90	Confident: backbone generally right	16%
50 to 70	Low: treat with caution	6%
Below 50	Very low: often disordered regions	2%

What pLDDT means and how to read it

Function

Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates

Subcellular location

Nucleus

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
9BZ0	EM	1.9 Å	C=1-275
9HVQ	EM	2.0 Å	C=1-275
7NVU	EM	2.5 Å	C=1-275
8QEP	EM	2.5 Å	C=1-275
8B3D	EM	2.6 Å	C=1-275
7OOB	EM	2.7 Å	C=1-275
8UHG	EM	2.7 Å	C=1-271
8UI0	EM	2.7 Å	C=1-271
8WAV	EM	2.72 Å	q=1-275
8WAX	EM	2.75 Å	q=1-275
8WAZ	EM	2.76 Å	q=1-275
7F4G	EM	2.78 Å	C=1-275
8WAU	EM	2.78 Å	q=1-275
7B7U	EM	2.8 Å	C=1-271
7NVS	EM	2.8 Å	C=1-275
7OO3	EM	2.8 Å	C=1-275
8OEW	EM	2.8 Å	C=1-275
8UHD	EM	2.8 Å	C=1-271
9HVO	EM	2.8 Å	C=1-275
8WAT	EM	2.82 Å	q=1-275

Showing 20 of 107 experimental structures (best resolution first).

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