Toll-like receptor 4 (TLR4) is a 839-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00206.
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The mean pLDDT of this model is 89.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:10835634, PubMed:15809303, PubMed:16622205, PubMed:17292937, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187, PubMed:27022195, PubMed:29038465, PubMed:17803912, PubMed:15852007). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+)…
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain (PubMed:17803912, PubMed:19252480). Interacts with MYD88 (PubMed:36232715). Interacts (via TIR domains) with TIRAP (By similarity). Interacts with TICAM2…
Cell membrane, Early endosome, Cell projection, ruffle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2Z62 | X-ray | 1.7 Å | A=27-228 |
| 2Z66 | X-ray | 1.9 Å | A/B/C/D=384-627 |
| 2Z63 | X-ray | 2.0 Å | A=27-530 |
| 8WO1 | EM | 2.24 Å | A/B=27-631 |
| 3UL7 | X-ray | 2.37 Å | A=28-226 |
| 4G8A | X-ray | 2.4 Å | A/B=23-629 |
| 3UL9 | X-ray | 2.45 Å | A=28-228 |
| 3UL8 | X-ray | 2.5 Å | A=27-228 |
| 2Z65 | X-ray | 2.7 Å | A/B=27-228 |
| 9J03 | EM | 2.7 Å | A/B=27-631 |
| 8WTA | EM | 2.9 Å | A/B=27-631 |
| 3FXI | X-ray | 3.1 Å | A/B=27-631 |
| 3ULA | X-ray | 3.6 Å | A/C=27-228 |
| 5NAM | NMR | A=623-670 | |
| 5NAO | NMR | A=623-657 |
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