Krev interaction trapped protein 1 (KRIT1) is a 736-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00522.
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The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization…
Interacts with CDH5 (PubMed:20332120). Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (via C-terminus FERM domain) with RAP1A (active GTP-bound form preferentially); the interaction does not induce the opening conformation of KRIT1. Interacts (via FERM domain) with RAP1B. Interacts (via N-terminus NPXY motif) with ITGB1BP1; the interaction induces the opening…
Cytoplasm, cytoskeleton, Cell membrane, Cell junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4HDO | X-ray | 1.67 Å | A=417-736 |
| 4JIF | X-ray | 1.7 Å | B=170-198 |
| 6OQ4 | X-ray | 1.75 Å | A=417-736 |
| 6OQ3 | X-ray | 1.85 Å | A=417-736 |
| 6UZK | X-ray | 1.92 Å | A=417-736 |
| 4DXA | X-ray | 1.95 Å | B=420-736 |
| 4HDQ | X-ray | 1.95 Å | A=417-736 |
| 8SU8 | X-ray | 2.01 Å | A=419-736 |
| 8T09 | X-ray | 2.15 Å | A=419-736 |
| 8T7V | X-ray | 2.25 Å | A=417-736 |
| 3U7D | X-ray | 2.49 Å | A/C=417-736 |
| 4DX8 | X-ray | 2.54 Å | H/I/J/K=1-198 |
| 5D68 | X-ray | 2.91 Å | A/B/C=259-736 |
| 4TKN | X-ray | 3.0 Å | D/E/F=225-237 |
| 9PVG | X-ray | 3.0 Å | E/F=227-255 |
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