Ubiquitin-conjugating enzyme E2 C (UBE2C) is a 179-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O00762.
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The mean pLDDT of this model is 88.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4YII | X-ray | 1.8 Å | U=27-179 |
| 1I7K | X-ray | 1.95 Å | A/B=1-179 |
| 8TAU | EM | 3.5 Å | Q=1-179 |
| 9N9R | EM | 3.9 Å | Q=29-173 |
| 9N9S | EM | 3.9 Å | Q=29-173 |
| 8TAR | EM | 4.0 Å | Q=29-173 |
| 5A31 | EM | 4.3 Å | Q=29-173 |
| 5KHR | EM | 6.1 Å | Q=1-179 |
| 5L9U | EM | 6.4 Å | U=1-179 |
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