5A31: Human APC-Cdh1-Hsl1-UbcH10 complex
Structure of the human APC-Cdh1-Hsl1-UbcH10 complex. Determined by electron microscopy at 4.3 Å resolution. Released 18 Nov 2015.
- Method
- Electron microscopy
- Resolution
- 4.3 Å
- Organism
- HOMO SAPIENS
- Chains
- 24
- Atoms
- 67,685
- Mol. weight
- 1166.49 kDa
- Ligands
- ZN
- Released
- 18 Nov 2015
Explore 5A31 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5A31 contains 435 α-helices and 163 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 69 helices, 52 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 13 | 1 | 1 |
| β-strand | 17-19 | 3 | 2 |
| α-helix | 23-30 | 8 | |
| α-helix | 40-46 | 7 | |
| β-strand | 73-78 | 6 | 3 |
| β-strand | 90-95 | 6 | 3 |
| β-strand | 99-103 | 5 | 3 |
| β-strand | 115-118 | 4 | 3 |
| β-strand | 123 | 1 | 4 |
| β-strand | 127-132 | 6 | 5 |
| β-strand | 147-154 | 8 | 5 |
| β-strand | 155 | 1 | 4 |
| β-strand | 159-163 | 5 | 5 |
| β-strand | 168-170 | 3 | 5 |
| β-strand | 177-180 | 4 | 6 |
| β-strand | 183 | 1 | 7 |
| β-strand | 186 | 1 | 7 |
| β-strand | 187-191 | 5 | 6 |
| β-strand | 210-213 | 4 | 6 |
| α-helix | 219-220 | 2 | |
| β-strand | 221-222 | 2 | 6 |
| β-strand | 224 | 1 | 8 |
| β-strand | 238 | 1 | 8 |
| β-strand | 245-250 | 6 | 9 |
| β-strand | 255-260 | 6 | 9 |
| β-strand | 265-269 | 5 | 9 |
| α-helix | 286-294 | 9 | |
| β-strand | 411-413 | 3 | 9 |
| α-helix | 425-427 | 3 | |
| β-strand | 430-434 | 5 | 10 |
| β-strand | 440-446 | 7 | 10 |
| β-strand | 451-459 | 9 | 10 |
| β-strand | 466-474 | 9 | 10 |
| β-strand | 478-482 | 5 | 11 |
| β-strand | 487-492 | 6 | 11 |
| β-strand | 496-500 | 5 | 11 |
| β-strand | 505-508 | 4 | 11 |
| β-strand | 510 | 1 | 1 |
| β-strand | 584-591 | 8 | 2 |
| β-strand | 594-599 | 6 | 2 |
| β-strand | 604-608 | 5 | 2 |
| α-helix | 609-611 | 3 | |
| α-helix | 616-628 | 13 | |
| α-helix | 632-646 | 15 | |
| α-helix | 656-666 | 11 | |
| α-helix | 759-776 | 18 | |
| α-helix | 782-797 | 16 | |
| α-helix | 801-809 | 9 | |
| α-helix | 840-842 | 3 | |
| α-helix | 844-853 | 10 | |
| α-helix | 868-881 | 14 | |
| α-helix | 925-936 | 12 | |
| α-helix | 943-945 | 3 | |
| α-helix | 949-964 | 16 | |
| α-helix | 972-977 | 6 | |
| α-helix | 981-983 | 3 | |
| α-helix | 1021-1027 | 7 | |
| α-helix | 1033-1040 | 8 | |
| α-helix | 1046 | 1 | |
| β-strand | 1047 | 1 | 12 |
| α-helix | 1048 | 1 | |
| α-helix | 1059-1087 | 29 | |
| β-strand | 1092 | 1 | 13 |
| α-helix | 1093-1095 | 3 | |
| α-helix | 1102-1104 | 3 | |
| β-strand | 1108-1111 | 4 | 12 |
| β-strand | 1116-1119 | 4 | 12 |
| α-helix | 1133-1145 | 13 | |
| β-strand | 1147 | 1 | 13 |
| α-helix | 1155-1160 | 6 | |
| α-helix | 1169-1182 | 14 | |
| α-helix | 1184-1187 | 4 | |
| α-helix | 1190-1199 | 10 | |
| α-helix | 1202-1216 | 15 | |
| α-helix | 1222-1231 | 10 | |
| α-helix | 1237 | 1 | |
| α-helix | 1247-1260 | 14 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1330 | 10 | |
| α-helix | 1360-1374 | 15 | |
| α-helix | 1381-1386 | 6 | |
| α-helix | 1393-1398 | 6 | |
| α-helix | 1401-1414 | 14 | |
| α-helix | 1423-1429 | 7 | |
| α-helix | 1432-1436 | 5 | |
| α-helix | 1454-1475 | 22 | |
| α-helix | 1482-1499 | 18 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1545 | 13 | |
| α-helix | 1552-1565 | 14 | |
| β-strand | 1572-1574 | 3 | 14 |
| α-helix | 1579-1587 | 9 | |
| α-helix | 1604-1609 | 6 | |
| α-helix | 1610-1613 | 4 | |
| β-strand | 1614-1616 | 3 | 14 |
| β-strand | 1620-1622 | 3 | 15 |
| β-strand | 1629 | 1 | 15 |
| β-strand | 1633-1639 | 7 | 16 |
| β-strand | 1646-1652 | 7 | 16 |
| α-helix | 1656-1657 | 2 | |
| α-helix | 1659 | 1 | |
| β-strand | 1663-1668 | 6 | 16 |
| β-strand | 1673 | 1 | 17 |
| β-strand | 1675-1678 | 4 | 16 |
| α-helix | 1685-1692 | 8 | |
| β-strand | 1696-1698 | 3 | 15 |
| α-helix | 1700 | 1 | |
| β-strand | 1701 | 1 | 17 |
| α-helix | 1702 | 1 | |
| α-helix | 1745-1750 | 6 | |
| α-helix | 1751-1755 | 5 | |
| α-helix | 1765-1780 | 16 | |
| α-helix | 1786-1802 | 17 | |
| α-helix | 1809-1821 | 13 | |
| α-helix | 1845-1862 | 18 | |
| α-helix | 1865-1872 | 8 | |
| α-helix | 1879-1892 | 14 | |
| α-helix | 1911-1919 | 9 | |
| α-helix | 1925-1933 | 9 | |
Chain B: 1 helix, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-9 | 7 | 18 |
| β-strand | 13 | 1 | 19 |
| β-strand | 16 | 1 | 20 |
| β-strand | 22 | 1 | 21 |
| β-strand | 29 | 1 | 21 |
| β-strand | 31 | 1 | 20 |
| β-strand | 46-48 | 3 | 22 |
| β-strand | 49 | 1 | 23 |
| β-strand | 54-56 | 3 | 22 |
| α-helix | 57-67 | 11 | |
| β-strand | 72 | 1 | 24 |
| β-strand | 79 | 1 | 24 |
| β-strand | 82 | 1 | 23 |
Chain C: 32 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-46 | 18 | |
| α-helix | 49-61 | 13 | |
| α-helix | 63-65 | 3 | |
| α-helix | 72-76 | 5 | |
| α-helix | 78-96 | 19 | |
| α-helix | 99-106 | 8 | |
| α-helix | 112-136 | 25 | |
| α-helix | 151-164 | 14 | |
| α-helix | 170-181 | 12 | |
| α-helix | 185-198 | 14 | |
| α-helix | 203-212 | 10 | |
| α-helix | 216-221 | 6 | |
| α-helix | 229-241 | 13 | |
| α-helix | 244-254 | 11 | |
| α-helix | 255-259 | 5 | |
| α-helix | 263-276 | 14 | |
| α-helix | 279-292 | 14 | |
| α-helix | 300-309 | 10 | |
| α-helix | 313-326 | 14 | |
| α-helix | 331-344 | 14 | |
| α-helix | 347-360 | 14 | |
| α-helix | 366-377 | 12 | |
| α-helix | 381-394 | 14 | |
| α-helix | 399-411 | 13 | |
| α-helix | 415-428 | 14 | |
| α-helix | 433-446 | 14 | |
| α-helix | 449-462 | 14 | |
| α-helix | 469-479 | 11 | |
| α-helix | 484-499 | 16 | |
| α-helix | 510-522 | 13 | |
| α-helix | 526-539 | 14 | |
| α-helix | 544-556 | 13 | |
Chain D: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| α-helix | 26-45 | 20 | |
| α-helix | 52-53 | 2 | |
Chain E: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 53-91 | 39 | |
| α-helix | 97-98 | 2 | |
| α-helix | 99-102 | 4 | |
Chain F: 31 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-35 | 15 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-63 | 10 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-93 | 9 | |
| α-helix | 104-110 | 7 | |
| α-helix | 111-113 | 3 | |
| α-helix | 114-128 | 15 | |
| α-helix | 131-144 | 14 | |
| α-helix | 149-157 | 9 | |
| α-helix | 162-163 | 2 | |
| α-helix | 452-478 | 27 | |
| α-helix | 481-489 | 9 | |
| α-helix | 499-511 | 13 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-546 | 11 | |
| α-helix | 549-562 | 14 | |
| α-helix | 567-579 | 13 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-614 | 14 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-682 | 14 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-750 | 14 | |
| α-helix | 753-766 | 14 | |
| α-helix | 770-781 | 12 | |
Chain G: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-7 | 4 | |
| α-helix | 13-24 | 12 | |
Chain H: 30 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-35 | 15 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-63 | 10 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-93 | 9 | |
| α-helix | 104-110 | 7 | |
| α-helix | 111-113 | 3 | |
| α-helix | 114-128 | 15 | |
| α-helix | 131-144 | 14 | |
| α-helix | 149-157 | 9 | |
| α-helix | 164-168 | 5 | |
| α-helix | 452-478 | 27 | |
| α-helix | 481-489 | 9 | |
| α-helix | 499-511 | 13 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-546 | 11 | |
| α-helix | 549-562 | 14 | |
| α-helix | 567-579 | 13 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-614 | 14 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-682 | 14 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-750 | 14 | |
| α-helix | 753-766 | 14 | |
14 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 1 | A | protein | 1441 | HOMO SAPIENS | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 11 | B | protein | 84 | HOMO SAPIENS | Q9NYG5 (AlphaFold model) |
| Cell division cycle protein 23 homolog | C, P | protein | 597 | HOMO SAPIENS | Q9UJX2 (AlphaFold model) |
| Anaphase-promoting complex subunit 15 | D | protein | 121 | HOMO SAPIENS | P60006 (AlphaFold model) |
| Anaphase-promoting complex subunit 16 | E | protein | 110 | HOMO SAPIENS | Q96DE5 |
| Anaphase-promoting complex subunit 3 | F, H | protein | 824 | HOMO SAPIENS | P30260 |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | HOMO SAPIENS | Q8NHZ8 |
| Anaphase-promoting complex subunit 4 | I | protein | 808 | HOMO SAPIENS | Q9UJX5 |
| Anaphase-promoting complex subunit 6 | J | protein | 620 | HOMO SAPIENS | Q13042 |
| Anaphase-promoting complex subunit 6 | K | protein | 620 | HOMO SAPIENS | Q13042 |
| Anaphase-promoting complex subunit 10 | L | protein | 185 | HOMO SAPIENS | Q9UM13 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | HOMO SAPIENS | Q9BS18 |
8 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>5A31_1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 (chains A)
MIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASEXXXXXXXXXXXKESWQLRKAVSE
IGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISEVEKCICI
LQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSPLPTMFSMLHPLDEITPLVCK
AQYVVDHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKAEEEXXXXXXXXXGGFXXXX
PIVPELCIDHLWAAAQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESTALIFGSVTN
IPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPATYIHSIRDPVHNRVTLELSN
GSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGASYHSEWNLFV
TCLMNMMGYTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLVQLARDLKLGPYVDHYY
RDYPTLASEPPSIYQWVSSCLKGEGAPPYPYLPGICERSRLVVLSIALYILSSLAERLVV
WMTNVGFILRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSAADDGMND
MNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSEHEFIEEKENRLLQLCQRTM
ALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFH
NGVAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLT
KGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIG
LVYQGTAHRHTAEVLLAEIGRPPGPEMEYATDRESYSLAAGLALGMVCLGHGSNLIGMSA
LNVPEQLYQYMVGGHSPSYQIKEGDTLNVDVTCPGATLALAMIYLKTNNRSIADWLRAPD
TMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENLNLETLSQAHVYII
AGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHNLETCLSVVLLSLAM
VMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALL
CALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVLYKGTQWYE
QTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLTQHLKSILSKDGVLYVKLRAGQLSY
KEDASEARAFKSAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEML
PAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQFMNSEFLPVVKCTIDNTLDQ
WLQVGGDMCVHAYLSPLESQLSMLACFAVYHSVPAPXXXXXXXXXXXXXXXXXXXXXXXX
X
Sequence of entity 2 (B), FASTA
>5A31_2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 (chains B)
MKVKIKCWNGVALWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 3 (C, P), FASTA
>5A31_3 CELL DIVISION CYCLE PROTEIN 23 HOMOLOG (chains C, P)
MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF
SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY
SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKLHQARELDGFGLYLYGVVLR
KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE
LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM
DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL
NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY
YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL
TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN
DTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
Sequence of entity 4 (D), FASTA
>5A31_4 ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 (chains D)
MSTLYPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASE
HYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWM
I
Sequence of entity 5 (E), FASTA
>5A31_5 ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 (chains E)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 6 (F, H), FASTA
>5A31_6 ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 (chains F, H)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLSLCSYN
CKESINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 7 (G, W), FASTA
>5A31_7 ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQM
INDRIGYKPQPKPNNRSSQFGSLEF
Sequence of entity 8 (I), FASTA
>5A31_8 ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTDDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESE
AENQQAGAAALAPEIVIKVEKLDPELDS
Sequence of entity 9 (J), FASTA
>5A31_9 ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 (chains J)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVNGLEKNLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVASEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIAMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 10 (K), FASTA
>5A31_10 ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 (chains K)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLEKNLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHKSCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 11 (L), FASTA
>5A31_11 ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 (chains L)
MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 12 (M), FASTA
>5A31_12 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 3 |
Primary citation
Atomic Structure of the Apc/C and its Mechanism of Protein Ubiquitination. Chang, L., Zhang, Z., Yang, J. et al. Nature (2015) 522:450. DOI 10.1038/NATURE14471 · PubMed
Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LGG 2.15 Å, The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1)
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
Browse structure collections
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