9N9R: Anaphase-promoting complex subunit 1
Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex. Determined by electron microscopy at 3.9 Å resolution. Released 16 Apr 2025.
- Method
- Electron microscopy
- Resolution
- 3.9 Å
- Organism
- Homo sapiens
- Chains
- 21
- Atoms
- 35,982
- Mol. weight
- 1227.18 kDa
- Ligands
- ZN
- Released
- 16 Apr 2025
Explore 9N9R in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9N9R contains 502 α-helices and 153 β-strands across 21 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 94 helices, 52 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-14 | 4 | |
| α-helix | 23-25 | 3 | |
| α-helix | 28-30 | 3 | |
| β-strand | 76-81 | 6 | 1 |
| β-strand | 84-96 | 13 | 1 |
| β-strand | 99-104 | 6 | 1 |
| β-strand | 112-118 | 7 | 1 |
| β-strand | 123-132 | 10 | 2 |
| α-helix | 144-146 | 3 | |
| β-strand | 147-155 | 9 | 2 |
| β-strand | 158-163 | 6 | 2 |
| β-strand | 168-172 | 5 | 2 |
| β-strand | 177-183 | 7 | 3 |
| β-strand | 186-191 | 6 | 3 |
| β-strand | 211-213 | 3 | 3 |
| α-helix | 218-220 | 3 | |
| β-strand | 221-222 | 2 | 3 |
| β-strand | 244-250 | 7 | 4 |
| β-strand | 255-260 | 6 | 4 |
| β-strand | 265-270 | 6 | 4 |
| β-strand | 272-273 | 2 | 5 |
| α-helix | 274-275 | 2 | |
| α-helix | 276-279 | 4 | |
| α-helix | 400-403 | 4 | |
| β-strand | 407-408 | 2 | 5 |
| β-strand | 411 | 1 | 4 |
| β-strand | 432 | 1 | 6 |
| α-helix | 436-438 | 3 | |
| β-strand | 441-446 | 6 | 6 |
| α-helix | 447-449 | 3 | |
| β-strand | 451-456 | 6 | 6 |
| β-strand | 457-459 | 3 | 7 |
| β-strand | 466-468 | 3 | 7 |
| β-strand | 474-475 | 2 | 6 |
| β-strand | 478-480 | 3 | 8 |
| β-strand | 489-491 | 3 | 8 |
| β-strand | 497 | 1 | 8 |
| β-strand | 498-501 | 4 | 9 |
| β-strand | 504-508 | 5 | 9 |
| β-strand | 584-590 | 7 | 10 |
| β-strand | 594-599 | 6 | 10 |
| β-strand | 604-608 | 5 | 10 |
| α-helix | 609-611 | 3 | |
| α-helix | 616-625 | 10 | |
| α-helix | 631-645 | 15 | |
| α-helix | 656-667 | 12 | |
| α-helix | 676-680 | 5 | |
| α-helix | 704-711 | 8 | |
| α-helix | 714-720 | 7 | |
| α-helix | 725-728 | 4 | |
| α-helix | 730-732 | 3 | |
| β-strand | 747-748 | 2 | 11 |
| α-helix | 754-758 | 5 | |
| α-helix | 759-772 | 14 | |
| α-helix | 773-775 | 3 | |
| α-helix | 777-779 | 3 | |
| α-helix | 781-783 | 3 | |
| α-helix | 786-796 | 11 | |
| α-helix | 800-809 | 10 | |
| α-helix | 811-813 | 3 | |
| β-strand | 821-822 | 2 | 11 |
| α-helix | 825-828 | 4 | |
| α-helix | 841-842 | 2 | |
| α-helix | 844-852 | 9 | |
| α-helix | 857-859 | 3 | |
| β-strand | 860 | 1 | 12 |
| α-helix | 868-882 | 15 | |
| β-strand | 896 | 1 | 12 |
| α-helix | 923-925 | 3 | |
| α-helix | 926-937 | 12 | |
| α-helix | 941-946 | 6 | |
| α-helix | 952-964 | 13 | |
| α-helix | 972-977 | 6 | |
| α-helix | 1021-1027 | 7 | |
| α-helix | 1033-1041 | 9 | |
| α-helix | 1046 | 1 | |
| β-strand | 1047-1048 | 2 | 13 |
| α-helix | 1059-1088 | 30 | |
| α-helix | 1094-1095 | 2 | |
| α-helix | 1103-1105 | 3 | |
| β-strand | 1108-1111 | 4 | 13 |
| β-strand | 1116-1119 | 4 | 13 |
| α-helix | 1131-1144 | 14 | |
| α-helix | 1155-1160 | 6 | |
| α-helix | 1166-1168 | 3 | |
| α-helix | 1169-1182 | 14 | |
| α-helix | 1184-1187 | 4 | |
| α-helix | 1190-1198 | 9 | |
| α-helix | 1202-1215 | 14 | |
| α-helix | 1222-1231 | 10 | |
| α-helix | 1237 | 1 | |
| α-helix | 1247-1261 | 15 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1329 | 9 | |
| α-helix | 1347-1349 | 3 | |
| α-helix | 1360-1375 | 16 | |
| α-helix | 1381-1386 | 6 | |
| α-helix | 1388-1390 | 3 | |
| α-helix | 1395-1397 | 3 | |
| α-helix | 1401-1413 | 13 | |
| α-helix | 1416-1418 | 3 | |
| α-helix | 1423-1428 | 6 | |
| α-helix | 1432-1441 | 10 | |
| α-helix | 1454-1475 | 22 | |
| α-helix | 1482-1500 | 19 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1542 | 10 | |
| α-helix | 1552-1565 | 14 | |
| β-strand | 1572 | 1 | 14 |
| α-helix | 1578-1587 | 10 | |
| α-helix | 1604-1612 | 9 | |
| β-strand | 1616 | 1 | 14 |
| β-strand | 1618 | 1 | 15 |
| β-strand | 1620-1623 | 4 | 16 |
| β-strand | 1628-1629 | 2 | 16 |
| β-strand | 1633-1637 | 5 | 17 |
| α-helix | 1638-1640 | 3 | |
| β-strand | 1649-1652 | 4 | 17 |
| β-strand | 1656 | 1 | 15 |
| α-helix | 1657-1659 | 3 | |
| α-helix | 1660-1662 | 3 | |
| β-strand | 1665-1668 | 4 | 17 |
| β-strand | 1673 | 1 | 18 |
| β-strand | 1676-1678 | 3 | 17 |
| α-helix | 1680-1682 | 3 | |
| α-helix | 1685-1692 | 8 | |
| β-strand | 1696-1699 | 4 | 16 |
| β-strand | 1701 | 1 | 18 |
| α-helix | 1702 | 1 | |
| α-helix | 1726-1732 | 7 | |
| α-helix | 1736-1739 | 4 | |
| α-helix | 1745-1750 | 6 | |
| α-helix | 1751-1755 | 5 | |
| α-helix | 1762-1764 | 3 | |
| α-helix | 1765-1780 | 16 | |
| α-helix | 1784-1786 | 3 | |
| α-helix | 1787-1800 | 14 | |
| α-helix | 1809-1822 | 14 | |
| α-helix | 1826-1830 | 5 | |
| α-helix | 1844-1863 | 20 | |
| α-helix | 1865-1872 | 8 | |
| α-helix | 1880-1889 | 10 | |
| α-helix | 1911-1917 | 7 | |
| α-helix | 1925-1935 | 11 | |
Chain C: 1 helix, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22-23 | 2 | 19 |
| β-strand | 28-29 | 2 | 19 |
| β-strand | 46-48 | 3 | 20 |
| β-strand | 49 | 1 | 21 |
| β-strand | 54-56 | 3 | 20 |
| α-helix | 57-66 | 10 | |
| β-strand | 72 | 1 | 22 |
| β-strand | 79 | 1 | 22 |
| β-strand | 82 | 1 | 21 |
Chain D: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-7 | 3 | |
| α-helix | 9-11 | 3 | |
| α-helix | 26-45 | 20 | |
Chain G: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-7 | 3 | |
| α-helix | 13-15 | 3 | |
| α-helix | 16-26 | 11 | |
Chain H: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-91 | 40 | |
| α-helix | 93-95 | 3 | |
| α-helix | 99-103 | 5 | |
Chain I: 26 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 13 | 1 | 23 |
| β-strand | 23-28 | 6 | 24 |
| β-strand | 35-39 | 5 | 24 |
| β-strand | 43-47 | 5 | 24 |
| β-strand | 54-58 | 5 | 24 |
| β-strand | 68-73 | 6 | 25 |
| β-strand | 80-84 | 5 | 25 |
| β-strand | 89-93 | 5 | 25 |
| β-strand | 100-105 | 6 | 25 |
| β-strand | 112-114 | 3 | 26 |
| α-helix | 120-122 | 3 | |
| α-helix | 142-145 | 4 | |
| α-helix | 148-151 | 4 | |
| α-helix | 161-169 | 9 | |
| β-strand | 176-179 | 4 | 26 |
| β-strand | 185-188 | 4 | 26 |
| β-strand | 194-198 | 5 | 26 |
| β-strand | 204-209 | 6 | 27 |
| β-strand | 216-222 | 7 | 27 |
| β-strand | 230 | 1 | 28 |
| β-strand | 231-237 | 7 | 27 |
| α-helix | 239-243 | 5 | |
| α-helix | 245-275 | 31 | |
| α-helix | 278-293 | 16 | |
| α-helix | 300-308 | 9 | |
| α-helix | 315-324 | 10 | |
| α-helix | 327-347 | 21 | |
| α-helix | 348-353 | 6 | |
| α-helix | 354-371 | 18 | |
| α-helix | 373-376 | 4 | |
| α-helix | 377-379 | 3 | |
| α-helix | 383-428 | 46 | |
| α-helix | 442-454 | 13 | |
| α-helix | 475-477 | 3 | |
| α-helix | 496-503 | 8 | |
| α-helix | 507-509 | 3 | |
| α-helix | 514-515 | 2 | |
| α-helix | 522-545 | 24 | |
| β-strand | 558 | 1 | 28 |
| α-helix | 561-563 | 3 | |
| β-strand | 574 | 1 | 29 |
| β-strand | 577 | 1 | 29 |
| β-strand | 583-592 | 10 | 29 |
| β-strand | 595-604 | 10 | 29 |
| β-strand | 615-619 | 5 | 29 |
| β-strand | 623 | 1 | 30 |
| β-strand | 636-643 | 8 | 31 |
| β-strand | 648-655 | 8 | 31 |
| α-helix | 660-662 | 3 | |
| β-strand | 664-670 | 7 | 31 |
| α-helix | 671-674 | 4 | |
| α-helix | 678-680 | 3 | |
| α-helix | 701 | 1 | |
| β-strand | 702-704 | 3 | 29 |
| β-strand | 707 | 1 | 30 |
| β-strand | 711-713 | 3 | 31 |
| β-strand | 719-725 | 7 | 23 |
| β-strand | 730-735 | 6 | 23 |
| β-strand | 741-745 | 5 | 23 |
Chain J: 35 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-34 | 14 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-60 | 7 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-88 | 4 | |
| α-helix | 89-93 | 5 | |
| α-helix | 100-102 | 3 | |
| α-helix | 103-110 | 8 | |
| α-helix | 111-113 | 3 | |
| α-helix | 114-127 | 14 | |
| α-helix | 132-144 | 13 | |
| α-helix | 149-157 | 9 | |
| α-helix | 164-167 | 4 | |
| α-helix | 447-478 | 32 | |
| α-helix | 481-489 | 9 | |
| α-helix | 493-496 | 4 | |
| α-helix | 499-512 | 14 | |
| α-helix | 515-527 | 13 | |
| α-helix | 536-546 | 11 | |
| α-helix | 549-560 | 12 | |
| α-helix | 567-579 | 13 | |
| α-helix | 583-595 | 13 | |
| α-helix | 601-613 | 13 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-681 | 13 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-750 | 14 | |
| α-helix | 753-766 | 14 | |
| α-helix | 770-773 | 4 | |
| α-helix | 775-779 | 5 | |
Chain K: 35 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-15 | 14 | |
| α-helix | 19-32 | 14 | |
| α-helix | 37-48 | 12 | |
| α-helix | 53-63 | 11 | |
| α-helix | 65-68 | 4 | |
| α-helix | 70-82 | 13 | |
| α-helix | 86-92 | 7 | |
| α-helix | 125-142 | 18 | |
| α-helix | 146-159 | 14 | |
| α-helix | 164-171 | 8 | |
| α-helix | 172-174 | 3 | |
| α-helix | 178-187 | 10 | |
| α-helix | 190-192 | 3 | |
| α-helix | 195-209 | 15 | |
| α-helix | 215-217 | 3 | |
| α-helix | 222-227 | 6 | |
| α-helix | 231-244 | 14 | |
| α-helix | 247-260 | 14 | |
| α-helix | 267-278 | 12 | |
| α-helix | 281-294 | 14 | |
| α-helix | 299-312 | 14 | |
| α-helix | 316-329 | 14 | |
| α-helix | 334-345 | 12 | |
| α-helix | 352-363 | 12 | |
| α-helix | 368-379 | 12 | |
| α-helix | 384-397 | 14 | |
| α-helix | 402-415 | 14 | |
| α-helix | 418-435 | 18 | |
| α-helix | 441-457 | 17 | |
| α-helix | 461-474 | 14 | |
| α-helix | 479-492 | 14 | |
| α-helix | 495-506 | 12 | |
| α-helix | 513-527 | 15 | |
| α-helix | 556-559 | 4 | |
| α-helix | 561-565 | 5 | |
13 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 1 | A | protein | 1944 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 11 | C | protein | 84 | Homo sapiens | Q9NYG5 (AlphaFold model) |
| Anaphase-promoting complex subunit 15 | D | protein | 56 | Homo sapiens | P60006 (AlphaFold model) |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 (AlphaFold model) |
| Anaphase-promoting complex subunit 16 | H | protein | 58 | Homo sapiens | Q96DE5 |
| Anaphase-promoting complex subunit 4 | I | protein | 808 | Homo sapiens | Q9UJX5 |
| Cell division cycle protein 27 homolog | J, P | protein | 824 | Homo sapiens | P30260 |
| Cell division cycle protein 16 homolog | K, S | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
| Anaphase-promoting complex subunit 2 | N | protein | 822 | Homo sapiens | Q9UJX6 |
| Anaphase-promoting complex subunit 5 | O | protein | 755 | Homo sapiens | Q9UJX4 |
4 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>9N9R_1 Anaphase-promoting complex subunit 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGEPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFEEQGGEPQNVATSSS
LTAHLRSLSKGDEPVEEPFQNYSSIHSQSRSTSEPSLHSREPEISNMAALSRAHEPALGV
HEFSGVQRFNIESHNQEPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSEPKP
LSKLLGELDEVVLLEPVPELRDSSKLHDELYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYNTDRLAWTRNFDFEGSLEPVIAPKKARPEETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFEFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKEPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 2 (C), FASTA
>9N9R_2 Anaphase-promoting complex subunit 11 (chains C)
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 3 (D), FASTA
>9N9R_3 Anaphase-promoting complex subunit 15 (chains D)
STLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKP
Sequence of entity 4 (G, W), FASTA
>9N9R_4 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLEEDPKSREQM
INDRIGYKPQPKPNNRSSQFGELEF
Sequence of entity 5 (H), FASTA
>9N9R_5 Anaphase-promoting complex subunit 16 (chains H)
ERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPS
Sequence of entity 6 (I), FASTA
>9N9R_6 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLEEEE
AENQQAGAAALAPEIVIKVEKLDPELDS
Sequence of entity 7 (J, P), FASTA
>9N9R_7 Cell division cycle protein 27 homolog (chains J, P)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPEEVLTEEPQDTIELNRLNLESENSKYSLNTDSSVSYIDSAVI
EPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALEPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKEVARIGQTGTKSVFSQEGNEREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDEETTKENEKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDELEITKLDSEIISEGKISTIEPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 8 (K, S), FASTA
>9N9R_8 Cell division cycle protein 16 homolog (chains K, S)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDEEGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIIEPPWDFREFEVEKQTAEETGLEPLEEERKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 9 (L), FASTA
>9N9R_9 Anaphase-promoting complex subunit 10 (chains L)
MTEPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 10 (M), FASTA
>9N9R_10 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Sequence of entity 11 (N), FASTA
>9N9R_11 Anaphase-promoting complex subunit 2 (chains N)
MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQEPLCAGCSSDKQQCWCRQALEQF
HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
GKVFLQDGPARPAEPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDEEDDSGEPEDW
VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFEPEREIR
NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
VVTGPALAEIDLQELQGYLQKKVRDQQLVYEAGVYRLPKNCS
Sequence of entity 12 (O), FASTA
>9N9R_12 Anaphase-promoting complex subunit 5 (chains O)
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRL
NQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFS
GTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELEER
DEGERKMEKEELDVEVREEEVECSGPLSQKQAEFFLSQQAELLKNDETKALEPASLQKEL
NNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSL
RYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVL
LEHEVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDI
SIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQ
GCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNS
IEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIA
LPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDK
GRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARL
YHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 4 |
Primary citation
APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons. Skrajna, A., Bodrug, T., Martinez-Chacin, R.C. et al. Nat Commun (2025) 16:2561-2561. DOI 10.1038/s41467-025-57384-7 · PubMed
Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LGG 2.15 Å, The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1)
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
Browse structure collections
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