5KHR: Anaphase-promoting complex subunit 1
Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C). Determined by electron microscopy at 6.1 Å resolution. Released 24 Aug 2016.
- Method
- Electron microscopy
- Resolution
- 6.1 Å
- Organisms
- Homo sapiens, Saccharomyces cerevisiae
- Chains
- 21
- Atoms
- 7,936
- Mol. weight
- 1231.16 kDa
- Released
- 24 Aug 2016
Explore 5KHR in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5KHR contains 359 α-helices and 109 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 53 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 23-27 | 5 | |
| β-strand | 73-78 | 6 | 1 |
| β-strand | 90-95 | 6 | 2 |
| β-strand | 99-103 | 5 | 3 |
| β-strand | 113-118 | 6 | 4 |
| β-strand | 127-132 | 6 | 5 |
| β-strand | 147-152 | 6 | 6 |
| β-strand | 158-162 | 5 | 7 |
| β-strand | 168-172 | 5 | 8 |
| β-strand | 177-180 | 4 | 9 |
| β-strand | 189-191 | 3 | 10 |
| β-strand | 245-250 | 6 | 11 |
| β-strand | 255-259 | 5 | 12 |
| β-strand | 266-269 | 4 | 13 |
| β-strand | 432-434 | 3 | 14 |
| β-strand | 440-445 | 6 | 15 |
| β-strand | 452-454 | 3 | 16 |
| β-strand | 488-492 | 5 | 17 |
| β-strand | 496-500 | 5 | 18 |
| β-strand | 505-508 | 4 | 19 |
| β-strand | 586-588 | 3 | 20 |
| β-strand | 594-598 | 5 | 21 |
| β-strand | 604-608 | 5 | 22 |
| α-helix | 616-628 | 13 | |
| α-helix | 632-646 | 15 | |
| α-helix | 656-668 | 13 | |
| α-helix | 759-775 | 17 | |
| α-helix | 782-789 | 8 | |
| α-helix | 801-809 | 9 | |
| α-helix | 844-853 | 10 | |
| α-helix | 868-881 | 14 | |
| α-helix | 925-936 | 12 | |
| α-helix | 941-945 | 5 | |
| α-helix | 949-964 | 16 | |
| α-helix | 972-977 | 6 | |
| α-helix | 981-984 | 4 | |
| α-helix | 1021-1027 | 7 | |
| α-helix | 1033-1040 | 8 | |
| α-helix | 1059-1087 | 29 | |
| β-strand | 1108-1111 | 4 | 23 |
| β-strand | 1116-1119 | 4 | 24 |
| α-helix | 1133-1145 | 13 | |
| α-helix | 1155-1161 | 7 | |
| α-helix | 1169-1182 | 14 | |
| α-helix | 1184-1187 | 4 | |
| α-helix | 1190-1192 | 3 | |
| α-helix | 1202-1216 | 15 | |
| α-helix | 1222-1229 | 8 | |
| α-helix | 1247-1260 | 14 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1330 | 10 | |
| α-helix | 1360-1374 | 15 | |
| α-helix | 1381-1386 | 6 | |
| α-helix | 1393-1398 | 6 | |
| α-helix | 1401-1414 | 14 | |
| α-helix | 1423-1429 | 7 | |
| α-helix | 1432-1436 | 5 | |
| α-helix | 1454-1475 | 22 | |
| α-helix | 1482-1499 | 18 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1545 | 13 | |
| α-helix | 1552-1565 | 14 | |
| α-helix | 1567-1570 | 4 | |
| β-strand | 1572-1574 | 3 | 25 |
| α-helix | 1579-1587 | 9 | |
| α-helix | 1604-1613 | 10 | |
| β-strand | 1614-1616 | 3 | 26 |
| β-strand | 1620-1622 | 3 | 27 |
| β-strand | 1633-1638 | 6 | 28 |
| β-strand | 1648-1652 | 5 | 29 |
| β-strand | 1663-1668 | 6 | 30 |
| β-strand | 1675-1678 | 4 | 31 |
| α-helix | 1685-1692 | 8 | |
| β-strand | 1696-1698 | 3 | 32 |
| α-helix | 1745-1755 | 11 | |
| α-helix | 1765-1780 | 16 | |
| α-helix | 1784-1802 | 19 | |
| α-helix | 1809-1821 | 13 | |
| α-helix | 1845-1862 | 18 | |
| α-helix | 1865-1872 | 8 | |
| α-helix | 1879-1892 | 14 | |
| α-helix | 1912-1919 | 8 | |
| α-helix | 1925-1930 | 6 | |
Chain B: 1 helix, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-10 | 8 | 33 |
| β-strand | 46-48 | 3 | 34 |
| β-strand | 54-56 | 3 | 35 |
| α-helix | 57-66 | 10 | |
Chain C: 27 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 30-46 | 17 | |
| α-helix | 49-61 | 13 | |
| α-helix | 78-95 | 18 | |
| α-helix | 99-108 | 10 | |
| α-helix | 113-136 | 24 | |
| α-helix | 151-164 | 14 | |
| α-helix | 169-181 | 13 | |
| α-helix | 185-198 | 14 | |
| α-helix | 203-212 | 10 | |
| α-helix | 216-221 | 6 | |
| α-helix | 228-241 | 14 | |
| α-helix | 244-261 | 18 | |
| α-helix | 263-276 | 14 | |
| α-helix | 279-292 | 14 | |
| α-helix | 300-309 | 10 | |
| α-helix | 313-326 | 14 | |
| α-helix | 331-343 | 13 | |
| α-helix | 347-360 | 14 | |
| α-helix | 365-377 | 13 | |
| α-helix | 381-394 | 14 | |
| α-helix | 399-411 | 13 | |
| α-helix | 415-428 | 14 | |
| α-helix | 433-438 | 6 | |
| α-helix | 442-446 | 5 | |
| α-helix | 449-462 | 14 | |
| α-helix | 469-479 | 11 | |
| α-helix | 484-499 | 16 | |
Chain E: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 53-95 | 43 | |
| α-helix | 99-102 | 4 | |
Chain F: 27 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-35 | 15 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-63 | 10 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-93 | 9 | |
| α-helix | 104-128 | 25 | |
| α-helix | 131-144 | 14 | |
| α-helix | 149-157 | 9 | |
| α-helix | 452-477 | 26 | |
| α-helix | 481-490 | 10 | |
| α-helix | 499-512 | 14 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-545 | 10 | |
| α-helix | 549-562 | 14 | |
| α-helix | 567-579 | 13 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-614 | 14 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-682 | 14 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-750 | 14 | |
| α-helix | 753-764 | 12 | |
Chains G and W: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-24 | 12 | |
Chain H: 28 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-35 | 15 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-63 | 10 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-93 | 9 | |
| α-helix | 104-128 | 25 | |
| α-helix | 131-144 | 14 | |
| α-helix | 149-157 | 9 | |
| α-helix | 165-168 | 4 | |
| α-helix | 452-477 | 26 | |
| α-helix | 481-490 | 10 | |
| α-helix | 499-512 | 14 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-545 | 10 | |
| α-helix | 549-562 | 14 | |
| α-helix | 567-579 | 13 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-614 | 14 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-682 | 14 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-750 | 14 | |
| α-helix | 753-766 | 14 | |
Chain I: 17 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 23-28 | 6 | 36 |
| β-strand | 35-39 | 5 | 37 |
| β-strand | 44-47 | 4 | 38 |
| α-helix | 50-52 | 3 | |
| β-strand | 54-58 | 5 | 39 |
| β-strand | 68-73 | 6 | 40 |
| β-strand | 79-84 | 6 | 41 |
| β-strand | 90-94 | 5 | 42 |
| β-strand | 112-117 | 6 | 43 |
| α-helix | 133-136 | 4 | |
| α-helix | 165-169 | 5 | |
| β-strand | 174-179 | 6 | 44 |
| β-strand | 184-189 | 6 | 45 |
| α-helix | 189-191 | 3 | |
| β-strand | 193-199 | 7 | 46 |
| β-strand | 204-210 | 7 | 47 |
| β-strand | 216-222 | 7 | 48 |
| β-strand | 233-237 | 5 | 49 |
| α-helix | 239-242 | 4 | |
| α-helix | 300-309 | 10 | |
| α-helix | 316-324 | 9 | |
| α-helix | 327-371 | 45 | |
| α-helix | 373-376 | 4 | |
| α-helix | 383-428 | 46 | |
| α-helix | 442-455 | 14 | |
| α-helix | 475-479 | 5 | |
| α-helix | 496-502 | 7 | |
| α-helix | 506-509 | 4 | |
| α-helix | 522-548 | 27 | |
| β-strand | 551-554 | 4 | 50 |
| β-strand | 574-578 | 5 | 51 |
| β-strand | 583-591 | 9 | 52 |
| β-strand | 596-604 | 9 | 53 |
| β-strand | 615-623 | 9 | 54 |
| β-strand | 636-643 | 8 | 55 |
| β-strand | 648-655 | 8 | 56 |
| β-strand | 664-670 | 7 | 57 |
| α-helix | 671-674 | 4 | |
| α-helix | 680-682 | 3 | |
| β-strand | 702-707 | 6 | 58 |
| β-strand | 711-714 | 4 | 59 |
| β-strand | 719-724 | 6 | 60 |
| β-strand | 730-735 | 6 | 61 |
| β-strand | 741-745 | 5 | 62 |
11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 1 | A | protein | 1944 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 11 | B | protein | 84 | Homo sapiens | Q9NYG5 (AlphaFold model) |
| Cell division cycle protein 23 homolog | C, P | protein | 597 | Homo sapiens | Q9UJX2 (AlphaFold model) |
| Anaphase-promoting complex subunit 16 | E | protein | 110 | Homo sapiens | Q96DE5 (AlphaFold model) |
| Cell division cycle protein 27 homolog | F, H | protein | 824 | Homo sapiens | P30260 |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 |
| Anaphase-promoting complex subunit 4 | I | protein | 818 | Homo sapiens | Q9UJX5 |
| Cell division cycle protein 16 homolog | J, K | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
| Anaphase-promoting complex subunit 2 | N | protein | 822 | Homo sapiens | Q9UJX6 |
| Anaphase-promoting complex subunit 5 | O | protein | 755 | Homo sapiens | Q9UJX4 |
4 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>5KHR_1 Anaphase-promoting complex subunit 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSS
LTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGV
HSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKP
LSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 2 (B), FASTA
>5KHR_2 Anaphase-promoting complex subunit 11 (chains B)
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 3 (C, P), FASTA
>5KHR_3 Cell division cycle protein 23 homolog (chains C, P)
MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF
SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY
SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLR
KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE
LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM
DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL
NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY
YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL
TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN
DTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
Sequence of entity 4 (E), FASTA
>5KHR_4 Anaphase-promoting complex subunit 16 (chains E)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 5 (F, H), FASTA
>5KHR_5 Cell division cycle protein 27 homolog (chains F, H)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 6 (G, W), FASTA
>5KHR_6 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQM
INDRIGYKPQPKPNNRSSQFGSLEF
Sequence of entity 7 (I), FASTA
>5KHR_7 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESE
AENQQAGAAALAPEIVIKVEKLDPELDSGGSLEVLFQG
Sequence of entity 8 (J, K), FASTA
>5KHR_8 Cell division cycle protein 16 homolog (chains J, K)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 9 (L), FASTA
>5KHR_9 Anaphase-promoting complex subunit 10 (chains L)
MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 10 (M), FASTA
>5KHR_10 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Sequence of entity 11 (N), FASTA
>5KHR_11 Anaphase-promoting complex subunit 2 (chains N)
MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF
HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW
VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFEPEREIR
NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
VVTGPALAEIDLQELQGYLQKKVRDQQLVYEAGVYRLPKNCS
Sequence of entity 12 (O), FASTA
>5KHR_12 Anaphase-promoting complex subunit 5 (chains O)
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRL
NQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFS
GTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR
DEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQAELLKNDETKALEPASLQKEL
NNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSL
RYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVL
LEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDI
SIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQ
GCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNS
IEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIA
LPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDK
GRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARL
YHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Primary citation
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Yamaguchi, M., VanderLinden, R., Weissmann, F. et al. Mol Cell (2016) 63:593-607. DOI 10.1016/j.molcel.2016.07.003 · PubMed
Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LGG 2.15 Å, The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1)
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
Browse structure collections
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