Protein Mdm4 (MDM4) is a 490-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15151.
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The mean pLDDT of this model is 60.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 54% |
What pLDDT means and how to read it
Contributes to p53/TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions
Component of a ternary complex composed of FAM193A, MDM4 and MDM2; interaction of FAM193A with MDM4 is mediated by the MDM4 RING-type zinc finger and results in MDM4 destabilization, leading to enhanced p53/TP53 transcriptional activity (PubMed:36897777). Although FAM193A interacts with MDM4 and MDM2, it does not affect formation of the p53-MDM2-MDM4 transcriptional repressor complex…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Q9Y | X-ray | 1.2 Å | A/B=14-111 |
| 3FEA | X-ray | 1.33 Å | A=14-111 |
| 3FE7 | X-ray | 1.35 Å | A=14-111 |
| 3FDO | X-ray | 1.4 Å | A=23-111 |
| 3LBJ | X-ray | 1.5 Å | E=23-111 |
| 4RXZ | X-ray | 1.55 Å | A/B=24-108 |
| 6Q9W | X-ray | 1.55 Å | A/B=14-111 |
| 3EQY | X-ray | 1.63 Å | A/B=24-108 |
| 7C3Y | X-ray | 1.63 Å | A=23-108 |
| 7C44 | X-ray | 1.65 Å | A=23-108 |
| 8HDG | X-ray | 1.73 Å | A/B/C/D=23-111 |
| 3JZP | X-ray | 1.74 Å | A=23-111 |
| 3JZO | X-ray | 1.8 Å | A=23-111 |
| 3JZQ | X-ray | 1.8 Å | A/B=23-111 |
| 3MQR | X-ray | 1.8 Å | B=395-404 |
| 3U15 | X-ray | 1.8 Å | A/B/C/D=14-111 |
| 7C3Q | X-ray | 1.8 Å | A=23-108 |
| 3DAB | X-ray | 1.9 Å | A/C/E/G=23-111 |
| 8IA5 | X-ray | 1.93 Å | A=23-111 |
| 2VYR | X-ray | 2.0 Å | A/B/C/D=16-116 |
Showing 20 of 39 experimental structures (best resolution first).
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