Axin-1 (AXIN1) is a 862-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15169.
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The mean pLDDT of this model is 61.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 50% |
What pLDDT means and how to read it
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7…
Homodimer (By similarity). Interacts with ZBED3; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations (By similarity). Component of the beta-catenin destruction complex, containing at least, CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through…
Cytoplasm, Nucleus, Membrane, Cell membrane, Late endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1DK8 | X-ray | 1.57 Å | A=74-220 |
| 7SXJ | X-ray | 1.85 Å | B=384-400 |
| 1EMU | X-ray | 1.9 Å | A=80-211 |
| 7SXF | X-ray | 1.94 Å | B=385-399 |
| 8RU3 | X-ray | 2.0 Å | P=468-479 |
| 7SXH | X-ray | 2.09 Å | B=385-400 |
| 4NM3 | X-ray | 2.1 Å | B=383-402 |
| 5WZZ | X-ray | 2.1 Å | E/F/G/H=375-394 |
| 8RU4 | X-ray | 2.13 Å | C=469-479 |
| 4NM5 | X-ray | 2.3 Å | B=383-402 |
| 4NM7 | X-ray | 2.3 Å | B=383-402 |
| 1O9U | X-ray | 2.4 Å | B=383-400 |
| 7SXG | X-ray | 2.4 Å | B=385-400 |
| 8VMG | X-ray | 2.45 Å | C/D=383-435 |
| 4NM0 | X-ray | 2.5 Å | B=383-402 |
| 4NU1 | X-ray | 2.5 Å | B=383-402 |
| 7Y1P | X-ray | 2.6 Å | A/B/C/D=74-220 |
| 3ZDI | X-ray | 2.64 Å | B=383-400 |
| 4B7T | X-ray | 2.77 Å | B=383-400 |
| 6JCK | X-ray | 3.09 Å | A=781-862 |
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