N-glycosylase/DNA lyase (OGG1) is a 345-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O15527.
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The mean pLDDT of this model is 92.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion
Nucleus, nucleoplasm, Nucleus speckle, Nucleus matrix, Nucleus, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8XWC | X-ray | 1.45 Å | A=12-345 |
| 2XHI | X-ray | 1.55 Å | A=1-345 |
| 5AN4 | X-ray | 1.6 Å | A=12-323 |
| 8XWU | X-ray | 1.68 Å | A=12-345 |
| 8XXK | X-ray | 1.7 Å | A=12-345 |
| 8XXG | X-ray | 1.82 Å | A=12-345 |
| 9NZ8 | X-ray | 1.85 Å | A=12-327 |
| 1M3Q | X-ray | 1.9 Å | A=12-325 |
| 6RLW | X-ray | 2.0 Å | AAA/BBB/CCC/DDD/EEE=11-327 |
| 7AYY | X-ray | 2.0 Å | AAA/BBB/CCC/DDD/EEE=11-327 |
| 9NZ9 | X-ray | 2.0 Å | A=12-327 |
| 1LWY | X-ray | 2.01 Å | A=12-327 |
| 2NOH | X-ray | 2.01 Å | A=12-327 |
| 1M3H | X-ray | 2.05 Å | A=12-325 |
| 1EBM | X-ray | 2.1 Å | A=9-325 |
| 1LWW | X-ray | 2.1 Å | A=12-327 |
| 2NOB | X-ray | 2.1 Å | A=12-327 |
| 1KO9 | X-ray | 2.15 Å | A=1-345 |
| 1N39 | X-ray | 2.2 Å | A=12-325 |
| 1N3A | X-ray | 2.2 Å | A=12-325 |
Showing 20 of 47 experimental structures (best resolution first).
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