U4/U6.U5 tri-snRNP-associated protein 1 (SART1) is a 800-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43290.
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The mean pLDDT of this model is 63.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 40% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA
Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Interacts with UBL5 (PubMed:25092792). Interacts with IVNS1ABP (via Kelch repeats) (PubMed:30538201)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4PYU | X-ray | 2.0 Å | C/D/H/L/P/T=117-135 |
| 8H6L | EM | 2.6 Å | 4J=1-800 |
| 8H6K | EM | 2.7 Å | 4J=1-800 |
| 6QW6 | EM | 2.92 Å | S=1-800 |
| 8Q7N | EM | 3.1 Å | S=1-800 |
| 8QOZ | EM | 3.1 Å | S=1-800 |
| 8QPE | EM | 3.1 Å | S=1-800 |
| 8H6E | EM | 3.2 Å | 4S=1-800 |
| 8H6J | EM | 3.25 Å | 4S=1-800 |
| 6QX9 | EM | 3.28 Å | S=1-800 |
| 8Y6O | EM | 3.38 Å | S=1-800 |
| 8QP8 | EM | 3.5 Å | S=1-800 |
| 8QPA | EM | 3.7 Å | S=1-800 |
| 8QPB | EM | 3.7 Å | S=1-800 |
| 6AHD | EM | 3.8 Å | 9=1-800 |
| 8QP9 | EM | 4.1 Å | S=1-800 |
| 8QZS | EM | 4.1 Å | S=1-800 |
| 8QPK | EM | 4.2 Å | S=1-800 |
| 8R09 | EM | 4.3 Å | S=1-800 |
| 8R0B | EM | 4.4 Å | S=1-800 |
Showing 20 of 26 experimental structures (best resolution first).
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