8QOZ: Pre-B+5'ss+ATPgammaS Complex
Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part). Determined by electron microscopy at 3.1 Å resolution. Released 22 May 2024.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organism
- Homo sapiens
- Chains
- 17
- Atoms
- 44,360
- Mol. weight
- 1194.31 kDa
- Ligands
- IHP
- Released
- 22 May 2024
Explore 8QOZ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8QOZ contains 268 α-helices and 153 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 7: 6 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 410-412 | 3 | 44 |
| β-strand | 419-421 | 3 | 44 |
| α-helix | 422-424 | 3 | |
| α-helix | 425-431 | 7 | |
| α-helix | 436-451 | 16 | |
| α-helix | 459-470 | 12 | |
| α-helix | 506-508 | 3 | |
| α-helix | 509-518 | 10 | |
Chain A: 100 helices, 55 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 60 | 1 | 8 |
| α-helix | 61-62 | 2 | |
| α-helix | 63-72 | 10 | |
| α-helix | 86-89 | 4 | |
| α-helix | 92-94 | 3 | |
| α-helix | 95-104 | 10 | |
| α-helix | 106-108 | 3 | |
| β-strand | 115-121 | 7 | 8 |
| β-strand | 127-129 | 3 | 8 |
| β-strand | 134-135 | 2 | 9 |
| α-helix | 137-156 | 20 | |
| α-helix | 163-165 | 3 | |
| α-helix | 174-177 | 4 | |
| α-helix | 186-187 | 2 | |
| β-strand | 229 | 1 | 10 |
| α-helix | 232-241 | 10 | |
| α-helix | 252-255 | 4 | |
| α-helix | 260-268 | 9 | |
| α-helix | 286-289 | 4 | |
| α-helix | 299-301 | 3 | |
| α-helix | 310-315 | 6 | |
| α-helix | 317-320 | 4 | |
| α-helix | 329-331 | 3 | |
| α-helix | 357-358 | 2 | |
| α-helix | 372-373 | 2 | |
| β-strand | 379 | 1 | 11 |
| α-helix | 398-405 | 8 | |
| α-helix | 409-411 | 3 | |
| β-strand | 415 | 1 | 10 |
| β-strand | 419-420 | 2 | 9 |
| α-helix | 428-432 | 5 | |
| α-helix | 434-436 | 3 | |
| α-helix | 441-459 | 19 | |
| α-helix | 463-466 | 4 | |
| β-strand | 482-488 | 7 | 8 |
| α-helix | 489-508 | 20 | |
| β-strand | 516-518 | 3 | 12 |
| β-strand | 524-526 | 3 | 12 |
| α-helix | 532-537 | 6 | |
| α-helix | 542-566 | 25 | |
| α-helix | 571-583 | 13 | |
| α-helix | 585-588 | 4 | |
| α-helix | 599-616 | 18 | |
| α-helix | 631-653 | 23 | |
| α-helix | 681-696 | 16 | |
| α-helix | 705-721 | 17 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-797 | 29 | |
| α-helix | 803-820 | 18 | |
| α-helix | 822-824 | 3 | |
| β-strand | 825 | 1 | 13 |
| α-helix | 826-829 | 4 | |
| α-helix | 835-848 | 14 | |
| β-strand | 856 | 1 | 4 |
| α-helix | 858-872 | 15 | |
| α-helix | 874-887 | 14 | |
| β-strand | 894-900 | 7 | 14 |
| β-strand | 905-910 | 6 | 14 |
| α-helix | 913-932 | 20 | |
| α-helix | 948-960 | 13 | |
| β-strand | 973-980 | 8 | 15 |
| β-strand | 981 | 1 | 16 |
| α-helix | 985-987 | 3 | |
| α-helix | 990-1000 | 11 | |
| β-strand | 1001 | 1 | 13 |
| α-helix | 1003-1012 | 10 | |
| β-strand | 1016-1019 | 4 | 14 |
| β-strand | 1022-1025 | 4 | 14 |
| α-helix | 1037-1052 | 16 | |
| α-helix | 1054-1062 | 9 | |
| α-helix | 1077-1080 | 4 | |
| β-strand | 1085-1089 | 5 | 15 |
| β-strand | 1094-1101 | 8 | 15 |
| α-helix | 1103-1116 | 14 | |
| α-helix | 1123-1125 | 3 | |
| α-helix | 1144-1160 | 17 | |
| β-strand | 1168 | 1 | 16 |
| β-strand | 1174-1178 | 5 | 15 |
| β-strand | 1185-1189 | 5 | 17 |
| β-strand | 1192-1196 | 5 | 17 |
| α-helix | 1199-1202 | 4 | |
| β-strand | 1213-1214 | 2 | 17 |
| β-strand | 1217 | 1 | 18 |
| β-strand | 1224 | 1 | 18 |
| β-strand | 1228-1232 | 5 | 17 |
| α-helix | 1234-1249 | 16 | |
| α-helix | 1256-1274 | 19 | |
| α-helix | 1277-1280 | 4 | |
| α-helix | 1282-1303 | 22 | |
| α-helix | 1307-1308 | 2 | |
| α-helix | 1314-1317 | 4 | |
| α-helix | 1320-1322 | 3 | |
| β-strand | 1332 | 1 | 1 |
| β-strand | 1334-1335 | 2 | 19 |
| α-helix | 1336 | 1 | |
| α-helix | 1337-1340 | 4 | |
| β-strand | 1342-1346 | 5 | 20 |
| β-strand | 1349-1354 | 6 | 20 |
| β-strand | 1363-1364 | 2 | 19 |
| α-helix | 1365-1367 | 3 | |
| α-helix | 1375-1398 | 24 | |
| α-helix | 1407-1409 | 3 | |
| α-helix | 1419-1423 | 5 | |
| β-strand | 1424 | 1 | 5 |
| α-helix | 1430-1432 | 3 | |
| α-helix | 1436-1442 | 7 | |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1468-1477 | 10 | |
| α-helix | 1480-1485 | 6 | |
| α-helix | 1490-1493 | 4 | |
| β-strand | 1502-1504 | 3 | 2 |
| α-helix | 1512-1515 | 4 | |
| α-helix | 1520-1526 | 7 | |
| α-helix | 1529-1537 | 9 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1553-1554 | 2 | 21 |
| α-helix | 1560 | 1 | |
| β-strand | 1561-1562 | 2 | 21 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1599 | 19 | |
| β-strand | 1606-1611 | 6 | 22 |
| β-strand | 1629-1639 | 11 | 22 |
| α-helix | 1640-1642 | 3 | |
| β-strand | 1643-1644 | 2 | 22 |
| β-strand | 1655-1667 | 13 | 22 |
| α-helix | 1676-1688 | 13 | |
| β-strand | 1700-1706 | 7 | 22 |
| β-strand | 1711-1716 | 6 | 22 |
| α-helix | 1723-1735 | 13 | |
| α-helix | 1738-1751 | 14 | |
| β-strand | 1753-1754 | 2 | 2 |
| β-strand | 1762-1763 | 2 | 23 |
| α-helix | 1769-1771 | 3 | |
| β-strand | 1778-1781 | 4 | 23 |
| β-strand | 1787-1791 | 5 | 24 |
| β-strand | 1799-1803 | 5 | 24 |
| β-strand | 1805-1810 | 6 | 23 |
| β-strand | 1816-1822 | 7 | 23 |
| α-helix | 1833-1851 | 19 | |
| β-strand | 1860-1863 | 4 | 23 |
| α-helix | 1866-1868 | 3 | |
| α-helix | 1870-1875 | 6 | |
| β-strand | 1883-1887 | 5 | 23 |
| α-helix | 1893-1898 | 6 | |
| α-helix | 1903-1907 | 5 | |
| β-strand | 1913-1918 | 6 | 23 |
| α-helix | 1923-1925 | 3 | |
| α-helix | 1929-1945 | 17 | |
| α-helix | 1949-1954 | 6 | |
| α-helix | 1969-1970 | 2 | |
| α-helix | 1973-1994 | 22 | |
| α-helix | 2004-2012 | 9 | |
| α-helix | 2021-2026 | 6 | |
| α-helix | 2070-2073 | 4 | |
Chain B: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 41 | 1 | 1 |
Chain C: 43 helices, 39 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 117-121 | 5 | |
| β-strand | 129-136 | 8 | 34 |
| α-helix | 142-153 | 12 | |
| α-helix | 172-177 | 6 | |
| β-strand | 184-190 | 7 | 34 |
| β-strand | 198-204 | 7 | 34 |
| α-helix | 209-211 | 3 | |
| α-helix | 212-220 | 9 | |
| β-strand | 224-230 | 7 | 34 |
| β-strand | 234 | 1 | 34 |
| α-helix | 237-248 | 12 | |
| β-strand | 252-258 | 7 | 34 |
| α-helix | 261 | 1 | |
| α-helix | 262-266 | 5 | |
| α-helix | 271-289 | 19 | |
| α-helix | 296-298 | 3 | |
| α-helix | 302-304 | 3 | |
| β-strand | 307-311 | 5 | 34 |
| β-strand | 316-318 | 3 | 34 |
| α-helix | 320-331 | 12 | |
| α-helix | 336-340 | 5 | |
| β-strand | 348-350 | 3 | 11 |
| β-strand | 355-357 | 3 | 11 |
| α-helix | 365-366 | 2 | |
| β-strand | 367 | 1 | 11 |
| α-helix | 368-369 | 2 | |
| α-helix | 370-374 | 5 | |
| α-helix | 375-386 | 12 | |
| α-helix | 392-399 | 8 | |
| α-helix | 412-424 | 13 | |
| α-helix | 428-437 | 10 | |
| α-helix | 441-452 | 12 | |
| β-strand | 453 | 1 | 35 |
| α-helix | 460-466 | 7 | |
| β-strand | 475-483 | 9 | 36 |
| β-strand | 490-498 | 9 | 36 |
| β-strand | 501-502 | 2 | 37 |
| β-strand | 505-509 | 5 | 36 |
| α-helix | 519-521 | 3 | |
| β-strand | 523-527 | 5 | 36 |
| β-strand | 530-534 | 5 | 36 |
| β-strand | 537-541 | 5 | 36 |
| β-strand | 543-544 | 2 | 37 |
| β-strand | 549-553 | 5 | 36 |
| β-strand | 563-566 | 4 | 36 |
| β-strand | 577 | 1 | 35 |
| α-helix | 578-580 | 3 | |
| β-strand | 588-594 | 7 | 38 |
| α-helix | 597-599 | 3 | |
| α-helix | 600-613 | 14 | |
| β-strand | 618-621 | 4 | 38 |
| β-strand | 627-631 | 5 | 38 |
| α-helix | 634-643 | 10 | |
| α-helix | 644-648 | 5 | |
| β-strand | 653-655 | 3 | 38 |
| α-helix | 656-658 | 3 | |
| β-strand | 659-660 | 2 | 38 |
| β-strand | 663-666 | 4 | 39 |
| β-strand | 674-677 | 4 | 40 |
| β-strand | 684-691 | 8 | 40 |
| α-helix | 692-693 | 2 | |
| α-helix | 696-701 | 6 | |
| α-helix | 711-720 | 10 | |
| α-helix | 726-730 | 5 | |
| β-strand | 732-736 | 5 | 40 |
| β-strand | 743-747 | 5 | 40 |
| α-helix | 756-761 | 6 | |
| α-helix | 763-775 | 13 | |
| β-strand | 783-784 | 2 | 39 |
| β-strand | 787-795 | 9 | 40 |
| α-helix | 800-802 | 3 | |
| α-helix | 805-822 | 18 | |
| β-strand | 825-838 | 14 | 39 |
| α-helix | 840-842 | 3 | |
| α-helix | 843-852 | 10 | |
| β-strand | 856-862 | 7 | 39 |
| α-helix | 863 | 1 | |
| β-strand | 869-876 | 8 | 39 |
| α-helix | 883-890 | 8 | |
| β-strand | 896-906 | 11 | 39 |
| α-helix | 907 | 1 | |
| α-helix | 929-941 | 13 | |
Chain D: 5 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-8 | 2 | 42 |
| α-helix | 11-20 | 10 | |
| β-strand | 25-31 | 7 | 42 |
| α-helix | 36-47 | 12 | |
| β-strand | 56-62 | 7 | 42 |
| α-helix | 67-69 | 3 | |
| α-helix | 70-73 | 4 | |
| β-strand | 79-84 | 6 | 42 |
| β-strand | 89-90 | 2 | 42 |
| β-strand | 91-93 | 3 | 43 |
| β-strand | 102 | 1 | 42 |
| α-helix | 109-124 | 16 | |
| β-strand | 129-131 | 3 | 43 |
Chain F: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 81-96 | 16 | |
| α-helix | 105-115 | 11 | |
| α-helix | 126-139 | 14 | |
Chain G: 10 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 242-254 | 13 | |
| α-helix | 276-277 | 2 | |
| α-helix | 278-280 | 3 | |
| α-helix | 288-291 | 4 | |
| α-helix | 298-300 | 3 | |
| α-helix | 309-314 | 6 | |
| α-helix | 319-327 | 9 | |
| α-helix | 330-353 | 24 | |
| α-helix | 357-359 | 3 | |
| α-helix | 367-375 | 9 | |
Chain J: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 442-465 | 24 | |
| α-helix | 470-475 | 6 | |
| α-helix | 481-484 | 4 | |
| α-helix | 493-518 | 26 | |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| U5 small nuclear ribonucleoprotein 200 kDa helicase | B | protein | 160 | Homo sapiens | O75643 (AlphaFold model) |
| Probable ATP-dependent RNA helicase DDX23 | G | protein | 820 | Homo sapiens | Q9BUQ8 (AlphaFold model) |
| U4/U6 small nuclear ribonucleoprotein Prp3 | J | protein | 683 | Homo sapiens | O43395 (AlphaFold model) |
| U4/U6 small nuclear ribonucleoprotein Prp31 | L | protein | 499 | Homo sapiens | Q8WWY3 (AlphaFold model) |
| U4/U6 small nuclear ribonucleoprotein Prp4 | F | protein | 522 | Homo sapiens | O43172 |
| Pre-mRNA-processing factor 6 | N | protein | 941 | Homo sapiens | O94906 |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 |
| Ubiquitin carboxyl-terminal hydrolase 39 | U | protein | 565 | Homo sapiens | Q53GS9 |
| U4/U6.U5 tri-snRNP-associated protein 1 | S | protein | 800 | Homo sapiens | O43290 |
| 116 kDa U5 small nuclear ribonucleoprotein component | C | protein | 972 | Homo sapiens | Q15029 |
| NHP2-like protein 1, N-terminally processed | M | protein | 128 | Homo sapiens | P55769 |
| Thioredoxin-like protein 4A | D | protein | 142 | Homo sapiens | P83876 |
5 more molecules are not listed.
Sequence of entity 1 (B), FASTA
>8QOZ_1 U5 small nuclear ribonucleoprotein 200 kDa helicase (chains B)
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLL
Sequence of entity 2 (G), FASTA
>8QOZ_2 Probable ATP-dependent RNA helicase DDX23 (chains G)
MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR
SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK
DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE
VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE
KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG
RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK
KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ
AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL
SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR
QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA
TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK
QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
Sequence of entity 3 (J), FASTA
>8QOZ_3 U4/U6 small nuclear ribonucleoprotein Prp3 (chains J)
MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTL
RFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVE
EEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPER
LPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGI
APPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEK
PSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAAR
KTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEH
PAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISN
LMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQG
VHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLH
RIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREH
FKKHGAEHYWDLALSESVLESTD
Sequence of entity 4 (L), FASTA
>8QOZ_4 U4/U6 small nuclear ribonucleoprotein Prp31 (chains L)
MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMF
AEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSK
RFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLS
EEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTN
LSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCT
LAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYR
KMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARI
SKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYF
SSMAEFLKVKGEKSGLMST
Sequence of entity 5 (F), FASTA
>8QOZ_5 U4/U6 small nuclear ribonucleoprotein Prp4 (chains F)
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGI
EAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPIT
LFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLW
IANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFS
PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA
ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH
QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY
HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP
GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
Sequence of entity 6 (N), FASTA
>8QOZ_6 Pre-mRNA-processing factor 6 (chains N)
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQM
KKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERR
EQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLT
PVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDM
RKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKS
VRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDAR
IMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNT
QMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRK
HTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRA
VAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEE
QKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLW
LESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHD
PHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKR
CESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Sequence of entity 7 (A), FASTA
>8QOZ_7 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 8 (U), FASTA
>8QOZ_8 Ubiquitin carboxyl-terminal hydrolase 39 (chains U)
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAR
EAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDF
EKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYE
IIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVL
QALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEML
QAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKL
PHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILA
KFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDL
REYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQ
MITLSEAYIQIWKRRDNDETNQQGA
Sequence of entity 9 (S), FASTA
>8QOZ_9 U4/U6.U5 tri-snRNP-associated protein 1 (chains S)
MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERG
GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI
EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLL
NQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEE
FGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERA
EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGL
RERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRA
DDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGG
APPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWE
EDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG
EENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVAR
VKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKL
TPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQK
TPYIVLSGSGKSMNANTITK
Sequence of entity 10 (C), FASTA
>8QOZ_10 116 kDa U5 small nuclear ribonucleoprotein component (chains C)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 11 (M), FASTA
>8QOZ_11 NHP2-like protein 1, N-terminally processed (chains M)
MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADA
EPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQ
QSIERLLV
Sequence of entity 12 (D), FASTA
>8QOZ_12 Thioredoxin-like protein 4A (chains D)
MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL
VDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVY
RGARKGRGLVVSPKDYSTKYRY
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
Primary citation
Structural insights into the cross-exon to cross-intron spliceosome switch. Zhang, Z., Kumar, V., Dybkov, O. et al. Nature (2024) 630:1012-1019. DOI 10.1038/s41586-024-07458-1 · PubMed
Other PDB entries of the same protein (UniProt O75643 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2Q0Z 2.0 Å, Crystal structure of Q9P172/Sec63 from Homo sapiens. Northeast Structural Genomics…
- 8BCE 2.05 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 76
- 8BC9 2.3 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 24
- 8BCC 2.35 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 39
- 8BCB 2.38 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 34
- 8BC8 2.39 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 18
- 8BCG 2.39 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 86
- 6S8Q 2.39 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1
- 9S2E 2.4 Å, Human intron-lariat spliceosome-Aquarius (ILSaqr)
- 8BCF 2.42 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 78
- 7BDK 2.52 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP
- 7BDJ 2.59 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS
Browse structure collections
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