8QPA: Pre-B+5'ssLNG Complex
Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part). Determined by electron microscopy at 3.7 Å resolution. Released 22 May 2024.
- Method
- Electron microscopy
- Resolution
- 3.7 Å
- Organism
- Homo sapiens
- Chains
- 17
- Atoms
- 43,455
- Mol. weight
- 1422.81 kDa
- Ligands
- IHP
- Released
- 22 May 2024
Explore 8QPA in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8QPA contains 255 α-helices and 168 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 7: 5 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 410-412 | 3 | 2 |
| β-strand | 419-421 | 3 | 2 |
| α-helix | 425-432 | 8 | |
| α-helix | 438-451 | 14 | |
| α-helix | 452-454 | 3 | |
| α-helix | 457-458 | 2 | |
| α-helix | 459-472 | 14 | |
Chain A: 101 helices, 64 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 60 | 1 | 9 |
| α-helix | 61-62 | 2 | |
| α-helix | 65-72 | 8 | |
| α-helix | 89-94 | 6 | |
| α-helix | 95-104 | 10 | |
| α-helix | 106-108 | 3 | |
| β-strand | 115-121 | 7 | 9 |
| β-strand | 127-129 | 3 | 9 |
| β-strand | 134-135 | 2 | 10 |
| α-helix | 137-157 | 21 | |
| α-helix | 163-165 | 3 | |
| α-helix | 174-177 | 4 | |
| α-helix | 178-182 | 5 | |
| α-helix | 186-191 | 6 | |
| α-helix | 193-196 | 4 | |
| α-helix | 201-204 | 4 | |
| β-strand | 228-229 | 2 | 11 |
| α-helix | 232-241 | 10 | |
| α-helix | 243-245 | 3 | |
| α-helix | 260-268 | 9 | |
| α-helix | 277-278 | 2 | |
| α-helix | 286-289 | 4 | |
| β-strand | 294 | 1 | 12 |
| α-helix | 299-301 | 3 | |
| α-helix | 310-315 | 6 | |
| α-helix | 357-358 | 2 | |
| α-helix | 397-405 | 9 | |
| α-helix | 409-412 | 4 | |
| β-strand | 415-416 | 2 | 11 |
| β-strand | 419-420 | 2 | 10 |
| α-helix | 428-431 | 4 | |
| α-helix | 441-459 | 19 | |
| α-helix | 463-466 | 4 | |
| α-helix | 472-478 | 7 | |
| β-strand | 482-488 | 7 | 9 |
| α-helix | 489-508 | 20 | |
| β-strand | 516-518 | 3 | 13 |
| β-strand | 524-526 | 3 | 13 |
| α-helix | 529-531 | 3 | |
| α-helix | 532-537 | 6 | |
| α-helix | 542-565 | 24 | |
| α-helix | 571-583 | 13 | |
| α-helix | 585-588 | 4 | |
| α-helix | 591-593 | 3 | |
| α-helix | 598-616 | 19 | |
| α-helix | 631-655 | 25 | |
| α-helix | 683-696 | 14 | |
| α-helix | 701-705 | 5 | |
| α-helix | 706-721 | 16 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-797 | 29 | |
| α-helix | 803-819 | 17 | |
| α-helix | 822-824 | 3 | |
| β-strand | 825 | 1 | 14 |
| α-helix | 826-827 | 2 | |
| α-helix | 835-851 | 17 | |
| β-strand | 855-856 | 2 | 5 |
| α-helix | 858-872 | 15 | |
| α-helix | 874-887 | 14 | |
| β-strand | 894-900 | 7 | 15 |
| β-strand | 905-910 | 6 | 15 |
| α-helix | 913-932 | 20 | |
| β-strand | 940 | 1 | 16 |
| α-helix | 948-960 | 13 | |
| β-strand | 973 | 1 | 17 |
| β-strand | 974-980 | 7 | 16 |
| β-strand | 981-982 | 2 | 18 |
| α-helix | 990-1000 | 11 | |
| β-strand | 1001 | 1 | 14 |
| α-helix | 1003-1013 | 11 | |
| β-strand | 1016-1018 | 3 | 15 |
| β-strand | 1023-1025 | 3 | 15 |
| α-helix | 1037-1061 | 25 | |
| α-helix | 1077-1080 | 4 | |
| β-strand | 1087-1090 | 4 | 16 |
| β-strand | 1094-1098 | 5 | 16 |
| β-strand | 1101 | 1 | 17 |
| α-helix | 1103-1116 | 14 | |
| α-helix | 1140-1141 | 2 | |
| β-strand | 1142 | 1 | 12 |
| α-helix | 1144-1160 | 17 | |
| β-strand | 1167-1168 | 2 | 18 |
| β-strand | 1174-1178 | 5 | 16 |
| β-strand | 1185-1188 | 4 | 19 |
| β-strand | 1192-1196 | 5 | 19 |
| β-strand | 1213-1215 | 3 | 19 |
| β-strand | 1227-1232 | 6 | 19 |
| α-helix | 1234-1249 | 16 | |
| α-helix | 1256-1271 | 16 | |
| α-helix | 1277-1280 | 4 | |
| α-helix | 1282-1303 | 22 | |
| α-helix | 1314-1317 | 4 | |
| β-strand | 1332 | 1 | 1 |
| β-strand | 1334 | 1 | 20 |
| β-strand | 1342-1345 | 4 | 21 |
| β-strand | 1350-1353 | 4 | 21 |
| α-helix | 1361-1363 | 3 | |
| β-strand | 1364 | 1 | 20 |
| α-helix | 1365-1367 | 3 | |
| α-helix | 1368-1371 | 4 | |
| α-helix | 1375-1399 | 25 | |
| α-helix | 1405-1408 | 4 | |
| α-helix | 1409-1411 | 3 | |
| α-helix | 1419-1421 | 3 | |
| β-strand | 1424 | 1 | 6 |
| α-helix | 1429-1432 | 4 | |
| α-helix | 1436-1442 | 7 | |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1450-1451 | 2 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1468-1478 | 11 | |
| α-helix | 1480-1485 | 6 | |
| α-helix | 1490-1493 | 4 | |
| β-strand | 1501-1503 | 3 | 22 |
| β-strand | 1504 | 1 | 3 |
| α-helix | 1508-1515 | 8 | |
| α-helix | 1520-1524 | 5 | |
| α-helix | 1529-1537 | 9 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1553-1554 | 2 | 23 |
| β-strand | 1561-1562 | 2 | 23 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1599 | 19 | |
| α-helix | 1602-1604 | 3 | |
| β-strand | 1606-1611 | 6 | 24 |
| α-helix | 1616-1619 | 4 | |
| β-strand | 1626 | 1 | 25 |
| β-strand | 1629-1639 | 11 | 24 |
| β-strand | 1643 | 1 | 24 |
| β-strand | 1655-1667 | 13 | 24 |
| α-helix | 1676-1688 | 13 | |
| β-strand | 1694 | 1 | 25 |
| β-strand | 1700-1706 | 7 | 24 |
| β-strand | 1711-1716 | 6 | 24 |
| α-helix | 1722-1735 | 14 | |
| α-helix | 1738-1751 | 14 | |
| β-strand | 1753-1755 | 3 | 22 |
| β-strand | 1763 | 1 | 26 |
| α-helix | 1769-1771 | 3 | |
| β-strand | 1777-1781 | 5 | 27 |
| β-strand | 1787-1791 | 5 | 28 |
| β-strand | 1792 | 1 | 29 |
| α-helix | 1797-1798 | 2 | |
| β-strand | 1799-1803 | 5 | 28 |
| β-strand | 1805-1806 | 2 | 30 |
| β-strand | 1808-1810 | 3 | 27 |
| β-strand | 1819-1820 | 2 | 8 |
| β-strand | 1821-1822 | 2 | 30 |
| α-helix | 1824-1826 | 3 | |
| α-helix | 1833-1851 | 19 | |
| α-helix | 1854-1856 | 3 | |
| β-strand | 1860-1863 | 4 | 27 |
| α-helix | 1866-1868 | 3 | |
| α-helix | 1869-1875 | 7 | |
| β-strand | 1883-1886 | 4 | 27 |
| β-strand | 1887 | 1 | 26 |
| α-helix | 1894-1898 | 5 | |
| α-helix | 1900-1907 | 8 | |
| β-strand | 1914-1916 | 3 | 8 |
| α-helix | 1923-1925 | 3 | |
| α-helix | 1929-1945 | 17 | |
| α-helix | 1947-1954 | 8 | |
| α-helix | 1973-1995 | 23 | |
| α-helix | 1999-2001 | 3 | |
| α-helix | 2004-2012 | 9 | |
Chain B: 2 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 40 | 1 | |
| β-strand | 41 | 1 | 1 |
| α-helix | 42 | 1 | |
Chain C: 37 helices, 41 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 117-124 | 8 | |
| β-strand | 129-133 | 5 | 43 |
| β-strand | 136 | 1 | 43 |
| α-helix | 142-153 | 12 | |
| α-helix | 172-177 | 6 | |
| β-strand | 185-191 | 7 | 43 |
| β-strand | 197-203 | 7 | 43 |
| α-helix | 209-211 | 3 | |
| α-helix | 212-219 | 8 | |
| β-strand | 224-230 | 7 | 43 |
| α-helix | 237-248 | 12 | |
| β-strand | 252-258 | 7 | 43 |
| α-helix | 262-266 | 5 | |
| α-helix | 271-292 | 22 | |
| β-strand | 307-311 | 5 | 43 |
| β-strand | 316-318 | 3 | 43 |
| α-helix | 320-331 | 12 | |
| α-helix | 336-340 | 5 | |
| β-strand | 348-349 | 2 | 44 |
| β-strand | 356-357 | 2 | 44 |
| β-strand | 367 | 1 | 44 |
| α-helix | 368-369 | 2 | |
| α-helix | 370-374 | 5 | |
| α-helix | 375-385 | 11 | |
| α-helix | 392-397 | 6 | |
| α-helix | 412-424 | 13 | |
| α-helix | 428-435 | 8 | |
| α-helix | 441-452 | 12 | |
| β-strand | 453 | 1 | 45 |
| α-helix | 460-465 | 6 | |
| β-strand | 475-483 | 9 | 46 |
| β-strand | 490-496 | 7 | 46 |
| β-strand | 501-502 | 2 | 47 |
| β-strand | 506-509 | 4 | 46 |
| β-strand | 523-526 | 4 | 46 |
| β-strand | 530-534 | 5 | 46 |
| β-strand | 537-540 | 4 | 46 |
| β-strand | 543-544 | 2 | 47 |
| β-strand | 548-552 | 5 | 46 |
| β-strand | 563-566 | 4 | 46 |
| β-strand | 577 | 1 | 45 |
| α-helix | 578-579 | 2 | |
| β-strand | 588-594 | 7 | 48 |
| α-helix | 597-599 | 3 | |
| α-helix | 600-612 | 13 | |
| β-strand | 620-621 | 2 | 48 |
| β-strand | 627-631 | 5 | 48 |
| α-helix | 634-643 | 10 | |
| α-helix | 644-649 | 6 | |
| β-strand | 653-655 | 3 | 48 |
| α-helix | 656-658 | 3 | |
| β-strand | 659-660 | 2 | 48 |
| β-strand | 663-666 | 4 | 49 |
| β-strand | 675-677 | 3 | 50 |
| β-strand | 684-690 | 7 | 50 |
| α-helix | 691-693 | 3 | |
| α-helix | 698-701 | 4 | |
| α-helix | 711-720 | 10 | |
| α-helix | 726-729 | 4 | |
| β-strand | 732 | 1 | 50 |
| β-strand | 744-747 | 4 | 50 |
| α-helix | 756-771 | 16 | |
| α-helix | 773-776 | 4 | |
| β-strand | 783-784 | 2 | 49 |
| β-strand | 788-795 | 8 | 50 |
| α-helix | 805-822 | 18 | |
| β-strand | 825-836 | 12 | 49 |
| β-strand | 839 | 1 | 51 |
| α-helix | 840-842 | 3 | |
| α-helix | 843-852 | 10 | |
| β-strand | 856-862 | 7 | 49 |
| α-helix | 863 | 1 | |
| β-strand | 868 | 1 | 51 |
| β-strand | 869-876 | 8 | 49 |
| α-helix | 883-888 | 6 | |
| β-strand | 897-906 | 10 | 49 |
| α-helix | 907 | 1 | |
| α-helix | 926-941 | 16 | |
Chain D: 5 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-8 | 2 | 53 |
| α-helix | 11-19 | 9 | |
| β-strand | 25-31 | 7 | 53 |
| α-helix | 36-41 | 6 | |
| α-helix | 44-47 | 4 | |
| β-strand | 56-62 | 7 | 53 |
| α-helix | 70-73 | 4 | |
| β-strand | 79-84 | 6 | 53 |
| β-strand | 89 | 1 | 53 |
| β-strand | 91-93 | 3 | 54 |
| α-helix | 109-125 | 17 | |
| β-strand | 129-131 | 3 | 54 |
Chain F: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 86-97 | 12 | |
| α-helix | 105-115 | 11 | |
| α-helix | 126-137 | 12 | |
Chain G: 11 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 242-254 | 13 | |
| α-helix | 276-277 | 2 | |
| α-helix | 278-280 | 3 | |
| α-helix | 288-291 | 4 | |
| α-helix | 298-300 | 3 | |
| α-helix | 309-315 | 7 | |
| α-helix | 319-327 | 9 | |
| α-helix | 330-332 | 3 | |
| α-helix | 334-353 | 20 | |
| α-helix | 357-359 | 3 | |
| α-helix | 367-375 | 9 | |
Chain J: 5 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 437 | 1 | 2 |
| α-helix | 442-466 | 25 | |
| α-helix | 470-475 | 6 | |
| α-helix | 481-484 | 4 | |
| α-helix | 486-489 | 4 | |
| α-helix | 493-518 | 26 | |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| U5 small nuclear ribonucleoprotein 200 kDa helicase | B | protein | 2136 | Homo sapiens | O75643 (AlphaFold model) |
| Probable ATP-dependent RNA helicase DDX23 | G | protein | 820 | Homo sapiens | Q9BUQ8 (AlphaFold model) |
| U4/U6 small nuclear ribonucleoprotein Prp3 | J | protein | 683 | Homo sapiens | O43395 (AlphaFold model) |
| U4/U6 small nuclear ribonucleoprotein Prp31 | L | protein | 499 | Homo sapiens | Q8WWY3 (AlphaFold model) |
| U4/U6 small nuclear ribonucleoprotein Prp4 | F | protein | 522 | Homo sapiens | O43172 |
| Pre-mRNA-processing factor 6 | N | protein | 941 | Homo sapiens | O94906 |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 |
| Ubiquitin carboxyl-terminal hydrolase 39 | U | protein | 565 | Homo sapiens | Q53GS9 |
| U4/U6.U5 tri-snRNP-associated protein 1 | S | protein | 800 | Homo sapiens | O43290 |
| 116 kDa U5 small nuclear ribonucleoprotein component | C | protein | 972 | Homo sapiens | Q15029 |
| NHP2-like protein 1, N-terminally processed | M | protein | 128 | Homo sapiens | P55769 |
| Thioredoxin-like protein 4A | D | protein | 142 | Homo sapiens | P83876 |
5 more molecules are not listed.
Sequence of entity 1 (B), FASTA
>8QPA_1 U5 small nuclear ribonucleoprotein 200 kDa helicase (chains B)
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTL
SANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDR
ECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGS
HFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKT
LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG
GERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYED
VATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPY
GFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGR
WTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTA
ALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSL
SSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVV
KKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKV
ELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYIT
PMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWK
QRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDV
AHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVI
VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYL
HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYP
IYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEI
VTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSK
CISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPI
RHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAI
RLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVE
SVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQ
LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG
AHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD
Sequence of entity 2 (G), FASTA
>8QPA_2 Probable ATP-dependent RNA helicase DDX23 (chains G)
MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSR
SRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRK
DRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQE
VEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREE
KDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLG
RGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQK
KLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQ
AIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVL
SRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYR
QTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVA
TDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELK
QAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
Sequence of entity 3 (J), FASTA
>8QPA_3 U4/U6 small nuclear ribonucleoprotein Prp3 (chains J)
MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTL
RFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVE
EEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPER
LPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGI
APPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEK
PSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAAR
KTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEH
PAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISN
LMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQG
VHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLH
RIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREH
FKKHGAEHYWDLALSESVLESTD
Sequence of entity 4 (L), FASTA
>8QPA_4 U4/U6 small nuclear ribonucleoprotein Prp31 (chains L)
MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMF
AEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSK
RFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLS
EEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTN
LSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCT
LAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYR
KMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARI
SKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYF
SSMAEFLKVKGEKSGLMST
Sequence of entity 5 (F), FASTA
>8QPA_5 U4/U6 small nuclear ribonucleoprotein Prp4 (chains F)
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGI
EAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPIT
LFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLW
IANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFS
PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA
ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH
QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGY
HIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP
GWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
Sequence of entity 6 (N), FASTA
>8QPA_6 Pre-mRNA-processing factor 6 (chains N)
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQM
KKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERR
EQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLT
PVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDM
RKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKS
VRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDAR
IMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNT
QMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRK
HTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRA
VAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEE
QKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLW
LESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHD
PHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKR
CESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Sequence of entity 7 (A), FASTA
>8QPA_7 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 8 (U), FASTA
>8QPA_8 Ubiquitin carboxyl-terminal hydrolase 39 (chains U)
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAR
EAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDF
EKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYE
IIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVL
QALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEML
QAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKL
PHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILA
KFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDL
REYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQ
MITLSEAYIQIWKRRDNDETNQQGA
Sequence of entity 9 (S), FASTA
>8QPA_9 U4/U6.U5 tri-snRNP-associated protein 1 (chains S)
MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERG
GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI
EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLL
NQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEE
FGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERA
EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGL
RERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRA
DDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGG
APPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWE
EDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG
EENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVAR
VKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKL
TPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQK
TPYIVLSGSGKSMNANTITK
Sequence of entity 10 (C), FASTA
>8QPA_10 116 kDa U5 small nuclear ribonucleoprotein component (chains C)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 11 (M), FASTA
>8QPA_11 NHP2-like protein 1, N-terminally processed (chains M)
MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADA
EPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQ
QSIERLLV
Sequence of entity 12 (D), FASTA
>8QPA_12 Thioredoxin-like protein 4A (chains D)
MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL
VDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVY
RGARKGRGLVVSPKDYSTKYRY
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
Primary citation
Structural insights into the cross-exon to cross-intron spliceosome switch. Zhang, Z., Kumar, V., Dybkov, O. et al. Nature (2024) 630:1012-1019. DOI 10.1038/s41586-024-07458-1 · PubMed
Other PDB entries of the same protein (UniProt O75643 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2Q0Z 2.0 Å, Crystal structure of Q9P172/Sec63 from Homo sapiens. Northeast Structural Genomics…
- 8BCE 2.05 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 76
- 8BC9 2.3 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 24
- 8BCC 2.35 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 39
- 8BCB 2.38 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 34
- 8BC8 2.39 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 18
- 8BCG 2.39 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 86
- 6S8Q 2.39 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1
- 9S2E 2.4 Å, Human intron-lariat spliceosome-Aquarius (ILSaqr)
- 8BCF 2.42 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 78
- 7BDK 2.52 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP
- 7BDJ 2.59 Å, Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS
Browse structure collections
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