U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) is a 683-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43395.
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The mean pLDDT of this model is 73.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 40% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)
Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:17932117, PubMed:26912367, PubMed:28781166, PubMed:9328476, PubMed:9404889). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6,…
Nucleus, Nucleus speckle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7N2R | X-ray | 2.28 Å | C=368-376 |
| 7N2S | X-ray | 2.37 Å | C=368-376 |
| 7N2N | X-ray | 2.6 Å | C=368-376 |
| 8H6L | EM | 2.6 Å | 4B=1-683 |
| 8H6K | EM | 2.7 Å | 4B=1-683 |
| 6QW6 | EM | 2.92 Å | 4A=1-683 |
| 8Q7N | EM | 3.1 Å | J=1-683 |
| 8QOZ | EM | 3.1 Å | J=1-683 |
| 8QPE | EM | 3.1 Å | J=1-683 |
| 8H6E | EM | 3.2 Å | 4B=1-683 |
| 8H6J | EM | 3.25 Å | 4B=1-683 |
| 6QX9 | EM | 3.28 Å | 4A=1-683 |
| 8Y6O | EM | 3.38 Å | N=1-683 |
| 8QP8 | EM | 3.5 Å | J=1-683 |
| 8QPA | EM | 3.7 Å | J=1-683 |
| 8QPB | EM | 3.7 Å | J=1-683 |
| 6AHD | EM | 3.8 Å | J=1-683 |
| 8QP9 | EM | 4.1 Å | J=1-683 |
| 8QZS | EM | 4.1 Å | J=1-683 |
| 8R09 | EM | 4.3 Å | J=1-683 |
Showing 20 of 30 experimental structures (best resolution first).
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