Serine protease HTRA2, mitochondrial (HTRA2) is a 458-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43464.
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The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560)
Homotrimer (PubMed:36758104, PubMed:36758105). Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis (PubMed:23479728)
Mitochondrion intermembrane space, Mitochondrion membrane, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5M3N | X-ray | 1.65 Å | A=134-458 |
| 5TO1 | X-ray | 1.69 Å | A=134-458 |
| 5M3O | X-ray | 1.7 Å | A=134-458 |
| 5TNY | X-ray | 1.7 Å | A=134-458 |
| 5TNZ | X-ray | 1.75 Å | A=134-458 |
| 5TO0 | X-ray | 1.9 Å | A=134-458 |
| 5FHT | X-ray | 1.95 Å | A=134-458 |
| 1LCY | X-ray | 2.0 Å | A=134-458 |
| 5WYN | X-ray | 2.05 Å | A=134-458 |
| 2PZD | X-ray | 2.75 Å | A/B=359-458 |
| 8E2K | EM | 3.21 Å | X/Y/Z=134-458 |
| 7VGE | X-ray | 4.0 Å | A/B/C=140-342, D/F=140-341, E=140-340 |
| 8AUK | EM | 6.2 Å | C/D/E=134-458 |
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