8E2K: BIRC6/HtrA2-S306A

Cryo-EM structure of BIRC6/HtrA2-S306A. Determined by electron microscopy at 3.21 Å resolution. Released 15 Feb 2023.

Method: Electron microscopy
Resolution: 3.21 Å
Organism: Homo sapiens
Chains: 5
Atoms: 47,903
Mol. weight: 1178.52 kDa
Released: 15 Feb 2023

Explore 8E2K in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8E2K contains 324 α-helices and 237 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 147 helices, 96 β-strands

Element	Residues	Length	Sheet
β-strand	75-76	2	1
β-strand	81-85	5	1
β-strand	91-95	5	1
β-strand	101-105	5	1
β-strand	116	1	2
β-strand	119-120	2	2
β-strand	125-129	5	2
β-strand	134-137	4	2
β-strand	140	1	3
β-strand	143	1	3
α-helix	151-154	4
β-strand	160-166	7	4
α-helix	167-175	9
α-helix	176-180	5
α-helix	189-203	15
α-helix	213-216	4
β-strand	218-224	7	4
α-helix	225-242	18
α-helix	248-262	15
α-helix	280-282	3
β-strand	285	1	5
α-helix	286-292	7
α-helix	293-295	3
α-helix	306-311	6
β-strand	314-316	3	6
β-strand	326-328	3	6
β-strand	334-335	2	6
α-helix	344-351	8
β-strand	366	1	5
α-helix	368-373	6
α-helix	375-377	3
β-strand	378	1	2
β-strand	388-390	3	7
β-strand	393	1	7
β-strand	394	1	8
β-strand	400-404	5	7
β-strand	408-413	6	7
β-strand	419-425	7	7
α-helix	431-436	6
β-strand	504-509	6	8
β-strand	512-513	2	8
β-strand	566-574	9	8
β-strand	626-634	9	8
β-strand	716-721	6	8
α-helix	722-723	2
α-helix	725-728	4
β-strand	731-738	8	9
β-strand	745-751	7	9
β-strand	823-828	6	9
β-strand	845-849	5	9
β-strand	856	1	10
β-strand	902-903	2	11
β-strand	906	1	11
β-strand	907	1	10
β-strand	912-916	5	11
β-strand	921-926	6	11
β-strand	940-945	6	12
β-strand	951-956	6	12
β-strand	961-965	5	12
α-helix	1019-1028	10
β-strand	1031-1033	3	13
α-helix	1037-1038	2
β-strand	1039-1041	3	14
β-strand	1046-1048	3	13
α-helix	1051-1054	4
α-helix	1063-1066	4
α-helix	1070-1073	4
β-strand	1074-1079	6	13
α-helix	1080	1
β-strand	1089-1094	6	14
β-strand	1101-1109	9	13
β-strand	1120-1126	7	14
α-helix	1172-1176	5
β-strand	1181-1187	7	14
α-helix	1188-1191	4
β-strand	1192	1	13
β-strand	1199-1203	5	13
α-helix	1206-1209	4
β-strand	1219-1226	8	14
α-helix	1292-1295	4
β-strand	1298-1306	9	13
α-helix	1307-1308	2
α-helix	1314-1323	10
α-helix	1325-1335	11
α-helix	1340-1342	3
α-helix	1346-1363	18
α-helix	1377-1383	7
α-helix	1385-1394	10
α-helix	1398-1413	16
α-helix	1421-1423	3
α-helix	1424-1435	12
α-helix	1436-1441	6
α-helix	1445-1458	14
α-helix	1463-1483	21
α-helix	1487-1496	10
β-strand	1564-1565	2	15
β-strand	1569-1573	5	16
β-strand	1578-1580	3	17
α-helix	1772-1775	4
β-strand	1777-1780	4	17
β-strand	1788-1794	7	16
β-strand	1800-1806	7	15
β-strand	1812-1820	9	16
α-helix	1824-1827	4
β-strand	1829-1834	6	16
β-strand	1842-1844	3	15
β-strand	1855-1862	8	16
α-helix	1863	1
β-strand	1871-1874	4	17
β-strand	1877-1881	5	15
α-helix	1886-1889	4
α-helix	1912-1940	29
α-helix	1950-1957	8
α-helix	1961-1997	37
α-helix	2012-2017	6
α-helix	2020-2039	20
α-helix	2056-2062	7
α-helix	2063-2067	5
α-helix	2072-2086	15
α-helix	2092-2104	13
α-helix	2114-2127	14
α-helix	2132-2146	15
α-helix	2147-2149	3
α-helix	2165-2181	17
α-helix	2200-2204	5
α-helix	2326-2341	16
β-strand	2347	1	18
α-helix	2348-2364	17
α-helix	2371-2374	4
α-helix	2377-2388	12
β-strand	2389	1	19
β-strand	2394	1	20
β-strand	2397	1	20
α-helix	2401-2419	19
β-strand	2568	1	16
α-helix	2569-2572	4
α-helix	2577-2598	22
α-helix	2636-2648	13
β-strand	2655	1	19
α-helix	2657-2668	12
α-helix	2690-2692	3
α-helix	2695-2697	3
α-helix	2698-2710	13
α-helix	2716-2730	15
α-helix	2748-2754	7
α-helix	2756-2767	12
β-strand	2777	1	21
α-helix	2782-2801	20
α-helix	2805-2820	16
α-helix	2825-2828	4
α-helix	2833-2844	12
β-strand	2852	1	22
α-helix	2853-2872	20
β-strand	2877-2878	2	23
α-helix	2886-2888	3
α-helix	2915-2930	16
α-helix	2932	1
β-strand	2933	1	24
β-strand	2934	1	25
β-strand	2940	1	22
β-strand	2941	1	25
β-strand	2979	1	24
α-helix	2980-2986	7
α-helix	2988-2999	12
α-helix	3032-3046	15
α-helix	3050-3061	12
α-helix	3065-3067	3
α-helix	3075-3077	3
α-helix	3079-3088	10
α-helix	3092-3100	9
α-helix	3103-3117	15
β-strand	3120	1	26
α-helix	3125-3132	8
β-strand	3161-3162	2	23
α-helix	3164-3166	3
β-strand	3168-3170	3	23
α-helix	3177-3178	2
α-helix	3180-3183	4
α-helix	3187-3189	3
β-strand	3197-3200	4	23
β-strand	3207-3227	21	23
α-helix	3232-3234	3
β-strand	3238-3244	7	23
β-strand	3251-3252	2	23
α-helix	3256	1
β-strand	3257-3258	2	23
β-strand	3265-3283	19	23
β-strand	3290-3301	12	23
α-helix	3306-3308	3
α-helix	3322-3325	4
α-helix	3328-3339	12
α-helix	3342-3352	11
α-helix	3358-3366	9
α-helix	3375-3386	12
α-helix	3390-3401	12
α-helix	3429-3440	12
α-helix	3446-3465	20
α-helix	3484-3487	4
α-helix	3491-3507	17
α-helix	3513-3516	4
α-helix	3519-3531	13
α-helix	3533	1
α-helix	3537-3552	16
α-helix	3554-3564	11
α-helix	3607-3616	10
α-helix	3620-3629	10
α-helix	3631-3644	14
α-helix	3680-3694	15
α-helix	3697-3703	7
α-helix	3709-3719	11
α-helix	3753-3771	19
α-helix	3775-3789	15
α-helix	3807-3815	9
β-strand	3821-3827	7	27
α-helix	3847-3849	3
β-strand	3855-3861	7	27
α-helix	3866-3871	6
β-strand	3966-3968	3	27
α-helix	3976-3978	3
α-helix	3983-3992	10
α-helix	3995-3996	2
β-strand	4001-4007	7	27
α-helix	4064-4069	6
α-helix	4070-4076	7
α-helix	4079-4086	8
α-helix	4155-4164	10
α-helix	4170-4174	5
α-helix	4178-4188	11
β-strand	4193	1	28
β-strand	4199	1	28
α-helix	4200-4202	3
α-helix	4206-4208	3
α-helix	4212-4222	11
α-helix	4229-4241	13
α-helix	4243-4255	13
α-helix	4306-4331	26
α-helix	4360-4366	7
α-helix	4369-4377	9
α-helix	4382-4387	6
α-helix	4389-4403	15
α-helix	4409-4411	3
α-helix	4433-4454	22
α-helix	4478-4498	21

Chain B: 147 helices, 94 β-strands

Element	Residues	Length	Sheet
β-strand	73-76	4	29
β-strand	81-85	5	29
β-strand	91-95	5	29
β-strand	101-105	5	29
β-strand	116	1	30
β-strand	119-120	2	30
β-strand	125-129	5	30
β-strand	134-137	4	30
β-strand	140	1	31
β-strand	143	1	31
α-helix	151-154	4
β-strand	160-166	7	32
α-helix	167-175	9
α-helix	176-180	5
α-helix	189-203	15
α-helix	213-216	4
β-strand	218-224	7	32
α-helix	225-242	18
α-helix	248-262	15
α-helix	280-282	3
β-strand	285	1	33
α-helix	286-292	7
α-helix	293-295	3
α-helix	306-311	6
β-strand	314-316	3	34
β-strand	326-328	3	34
β-strand	334-335	2	34
α-helix	344-351	8
β-strand	366	1	33
α-helix	368-373	6
α-helix	375-377	3
β-strand	378	1	30
β-strand	388-390	3	35
β-strand	393	1	35
β-strand	394	1	36
β-strand	400-404	5	35
β-strand	408-413	6	35
α-helix	415-418	4
β-strand	419-425	7	35
α-helix	431-436	6
β-strand	504-513	10	36
β-strand	566-574	9	36
β-strand	626-634	9	36
β-strand	716-721	6	36
α-helix	722-723	2
α-helix	724-729	6
β-strand	731-738	8	37
β-strand	745-751	7	37
β-strand	823-828	6	37
β-strand	845-849	5	37
β-strand	856	1	38
β-strand	902-903	2	39
β-strand	906	1	39
β-strand	907	1	38
β-strand	912-916	5	39
β-strand	921-926	6	39
β-strand	940-945	6	40
β-strand	951-956	6	40
β-strand	961-965	5	40
α-helix	1019-1028	10
β-strand	1031-1033	3	41
α-helix	1037-1038	2
β-strand	1039-1041	3	42
β-strand	1046-1048	3	41
α-helix	1051-1054	4
α-helix	1063-1066	4
α-helix	1070-1072	3
β-strand	1074-1079	6	41
α-helix	1080	1
β-strand	1089-1094	6	42
β-strand	1101-1109	9	41
β-strand	1120-1126	7	42
α-helix	1172-1176	5
β-strand	1181-1187	7	42
α-helix	1188-1191	4
β-strand	1192	1	41
β-strand	1199-1203	5	41
α-helix	1206-1209	4
β-strand	1219-1226	8	42
α-helix	1292-1295	4
β-strand	1298-1306	9	41
α-helix	1307-1308	2
α-helix	1314-1323	10
α-helix	1325-1335	11
α-helix	1340-1342	3
α-helix	1346-1363	18
α-helix	1377-1383	7
α-helix	1385-1394	10
α-helix	1398-1413	16
α-helix	1421-1423	3
α-helix	1424-1436	13
α-helix	1439-1441	3
α-helix	1445-1458	14
α-helix	1463-1483	21
α-helix	1487-1496	10
β-strand	1564-1565	2	43
β-strand	1569-1573	5	44
β-strand	1578-1580	3	45
α-helix	1772-1775	4
β-strand	1777-1780	4	45
β-strand	1788-1794	7	44
β-strand	1800-1806	7	43
β-strand	1812-1820	9	44
α-helix	1824-1827	4
β-strand	1829-1834	6	44
β-strand	1842-1845	4	43
β-strand	1855-1862	8	44
α-helix	1863	1
β-strand	1871-1874	4	45
β-strand	1877-1881	5	43
α-helix	1886-1889	4
α-helix	1912-1940	29
α-helix	1950-1957	8
α-helix	1961-1997	37
α-helix	2012-2017	6
α-helix	2020-2039	20
α-helix	2056-2062	7
α-helix	2063-2067	5
α-helix	2072-2086	15
α-helix	2092-2104	13
α-helix	2114-2127	14
α-helix	2132-2146	15
α-helix	2147-2149	3
α-helix	2165-2181	17
α-helix	2200-2204	5
α-helix	2326-2341	16
β-strand	2347	1	26
α-helix	2348-2364	17
α-helix	2371-2374	4
α-helix	2377-2388	12
β-strand	2389	1	46
β-strand	2394	1	47
β-strand	2397	1	47
α-helix	2401-2419	19
α-helix	2569-2572	4
α-helix	2577-2598	22
α-helix	2636-2648	13
β-strand	2655	1	46
α-helix	2657-2668	12
α-helix	2690-2692	3
α-helix	2695-2696	2
α-helix	2698-2710	13
α-helix	2716-2730	15
α-helix	2748-2754	7
α-helix	2756-2767	12
β-strand	2777	1	23
α-helix	2782-2801	20
α-helix	2805-2820	16
α-helix	2825-2828	4
α-helix	2833-2843	11
β-strand	2852	1	48
α-helix	2853-2872	20
β-strand	2877-2879	3	21
α-helix	2886-2888	3
α-helix	2915-2930	16
α-helix	2932	1
β-strand	2933	1	49
β-strand	2934	1	50
β-strand	2940	1	48
β-strand	2941	1	50
β-strand	2979	1	49
α-helix	2980-2986	7
α-helix	2988-2999	12
α-helix	3032-3046	15
α-helix	3050-3061	12
α-helix	3065-3067	3
α-helix	3075-3077	3
α-helix	3079-3088	10
α-helix	3092-3100	9
α-helix	3103-3117	15
β-strand	3120	1	18
α-helix	3125-3132	8
β-strand	3161-3162	2	21
α-helix	3164-3166	3
β-strand	3168-3170	3	21
α-helix	3177-3178	2
α-helix	3180-3183	4
α-helix	3187-3189	3
β-strand	3197-3200	4	21
β-strand	3207-3227	21	21
α-helix	3229-3234	6
β-strand	3238-3244	7	21
β-strand	3251-3252	2	21
α-helix	3256	1
β-strand	3257-3258	2	21
β-strand	3265-3283	19	21
β-strand	3290-3301	12	21
α-helix	3306-3308	3
α-helix	3322-3325	4
α-helix	3328-3339	12
α-helix	3342-3352	11
α-helix	3358-3366	9
α-helix	3375-3386	12
α-helix	3390-3401	12
α-helix	3429-3440	12
α-helix	3446-3465	20
α-helix	3484-3487	4
α-helix	3491-3505	15
α-helix	3513-3516	4
α-helix	3519-3531	13
α-helix	3533	1
α-helix	3537-3552	16
α-helix	3554-3564	11
α-helix	3607-3616	10
α-helix	3620-3629	10
α-helix	3631-3644	14
α-helix	3680-3694	15
α-helix	3697-3703	7
α-helix	3709-3719	11
α-helix	3753-3771	19
α-helix	3775-3789	15
α-helix	3807-3815	9
β-strand	3821-3827	7	51
α-helix	3847-3849	3
β-strand	3855-3861	7	51
α-helix	3866-3871	6
β-strand	3966-3968	3	51
α-helix	3976-3978	3
α-helix	3983-3992	10
α-helix	3995-3996	2
β-strand	4001-4007	7	51
α-helix	4064-4069	6
α-helix	4070-4076	7
α-helix	4079-4086	8
α-helix	4155-4164	10
α-helix	4170-4174	5
α-helix	4178-4188	11
β-strand	4193	1	52
β-strand	4199	1	52
α-helix	4206-4208	3
α-helix	4212-4222	11
α-helix	4229-4241	13
α-helix	4243-4255	13
α-helix	4306-4331	26
α-helix	4359-4366	8
α-helix	4369-4377	9
α-helix	4382-4387	6
α-helix	4389-4403	15
α-helix	4409-4411	3
α-helix	4433-4454	22
α-helix	4478-4498	21

Chain X: 9 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	143-147	5
α-helix	149-157	9
α-helix	158-160	3
β-strand	161-169	9	53
β-strand	176-188	13	53
β-strand	192-196	5	53
β-strand	205-209	5	53
β-strand	215-224	10	53
β-strand	229-234	6	53
β-strand	245	1	54
β-strand	256-259	4	54
β-strand	271-275	5	54
β-strand	295-297	3	54
β-strand	309-312	4	54
β-strand	317-326	10	54
β-strand	329-334	6	54
α-helix	335-342	8
β-strand	359-361	3	55
β-strand	364-368	5	56
α-helix	369-370	2
α-helix	371-380	10
β-strand	391-396	6	56
α-helix	401-405	5
β-strand	412-416	5	56
β-strand	419-420	2	56
α-helix	421	1
α-helix	424-433	10
β-strand	437-443	7	56
β-strand	446-452	7	56
β-strand	455-457	3	55

Chain Y: 11 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	143-147	5
α-helix	149-157	9
α-helix	158-160	3
β-strand	161-170	10	57
β-strand	175-188	14	57
β-strand	192-195	4	57
α-helix	197-200	4
β-strand	205-210	6	57
β-strand	215-224	10	57
β-strand	229-233	5	57
α-helix	239-241	3
α-helix	244	1
β-strand	245	1	58
α-helix	246	1
α-helix	248-250	3
α-helix	251-252	2
β-strand	256-259	4	58
β-strand	271-275	5	58
α-helix	294	1
β-strand	295-297	3	58
β-strand	309-312	4	58
β-strand	317-326	10	58
β-strand	329-334	6	58
α-helix	335-342	8

Chain Z: 10 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	143-147	5
α-helix	149-157	9
α-helix	158-160	3
β-strand	161-170	10	59
β-strand	175-188	14	59
β-strand	192-195	4	59
β-strand	205-209	5	59
β-strand	215-224	10	59
β-strand	229-233	5	59
α-helix	239-241	3
α-helix	243-244	2
β-strand	245	1	60
α-helix	246	1
α-helix	248-250	3
α-helix	251-252	2
β-strand	256-259	4	60
β-strand	271-274	4	60
α-helix	294	1
β-strand	295-297	3	60
β-strand	309-312	4	60
β-strand	317-326	10	60
β-strand	329-334	6	60
α-helix	335-342	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Baculoviral IAP repeat-containing protein 6	A, B	protein	4898	Homo sapiens	Q9NR09
Serine protease HTRA2, mitochondrial	X, Y, Z	protein	332	Homo sapiens	O43464 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>8E2K_1 Baculoviral IAP repeat-containing protein 6 (chains A, B)
MGDYKDHDGDYKDHDIDYKDDDDKGGGSGGLEVLFQGPSRTMVTGGGAAPPGTVTEPLPS
VIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPAL
NAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKD
LNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDG
LKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRL
SYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPA
SSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKGEHTQNVPLSVTLATSPAQF
PCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLIL
SGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKE
AMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGANPCLTNSKSEKTKEKHQEQ
HNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELN
SPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLL
LQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCLRLPKFAEEENLCIDSITPC
ADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVI
QHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSL
ILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTLGHLVITTQGGYVKILDLSN
FEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDDIDEADIL
VDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFS
ATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQTDSNSWDEHVFELVLPKAC
MVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSLVDLNEEMQH
MDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLTSPKLVKGMAGGKYRS
FLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLASLLAKVAAGKEKSSNVKNE
NTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKT
DDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRS
IAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLPAATTGGSVYWYFVLLNYVK
DEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYSSPFDPVLFDLEMSGSSCKN
VYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRI
ERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSLSHAMASAEQQLQVLQEKQQ
QLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNPVAAPGFFIHPSDVIPPTPK
TTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNSNKSRMNPLGSGL
ALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPILLTDVLIPTCGDLASLSIDI
WTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFYY
GHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLL
QSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVALG
ASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVLQSTFHAQAC
EELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFM
LLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTEGVLDIPMISWVVMLVSRLL
DYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHK
QQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWS
RSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLLSMDFTCHADLLLFVCKVLA
RIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGE
LLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETIDEPLTHDITGAPPLSSLEK
DKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTWYDYWGADYGTYNYNPYIGG
LGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALT
NTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSMLQVHHVQLES
LLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQASITSFLTVLAWYPNTLLRTW
CLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIHVLVKFLSGTSPHGTNQHSP
QVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKL
LEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSRSGSDSSVGARACFGGLFAN
LIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARVSVTTNTTDSVSDEEK
VSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGLCNSSAMAMIIGASGLHLTK
HENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTYMACGYMGRQGSLATCQLSE
PLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNK
AVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSY
IFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVSVEVSADGVNMLPLSTPVVT
SGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLGLTAFGTTSSATVNNPFLPS
EDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIE
VVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLFGRLNGLSSDSTIDILYQLG
TTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAA
ILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKKAVDSLLCSMCHVHPNYFSL
LMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQAPLALTESHLATLASSSQS
PEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDISQDKLRRHHVPQQCNKMPIT
ADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSAR
SASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQRGNLP
TSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYGAGHKFRTLH
LPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKEKVKAENGFQDNYSVVVASG
LKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKIITVPVFHLFHKLLAGQPLPA
EMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLAS
CPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVS
APVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTMSPIPAHSLA
AFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRS
LFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPRVPNSSVNQTEPQVSSSHNP
TSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSSAVN
GEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRALLELL
RAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVDTYTNRLRSKRENVK
TGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQEKKLGEYSKKAAMKPKPLS
VLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYMSQVKNANDANSAARARRLA
QEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSS
PPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLI
LVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPCFKEVIHKHF
YLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLKLPCPEGLDP
DTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL

Sequence of entity 2 (X, Y, Z), FASTA

>8E2K_2 Serine protease HTRA2, mitochondrial (chains X, Y, Z)
MAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGL
IVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVR
QGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNAGGPLVN
LDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPS
ILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVR
TQSQLAVQIRRGRETLTLYVTPEVTEHHHHHH

Primary citation

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Hunkeler, M., Jin, C.Y., Fischer, E.S. Science (2023) 379:1105-1111. DOI 10.1126/science.ade5750 · PubMed

Other PDB entries of the same protein (UniProt Q9NR09), best resolution first:

8E2E 1.98 Å, Cryo-EM structure of helical arch of BIRC6 (from local refinement 1)
3CEG 2.01 Å, Crystal structure of the UBC domain of baculoviral IAP repeat-containing protein 6
8E2D 2.07 Å, Cryo-EM structure of BIRC6 (consensus)
8E2H 2.3 Å, Cryo-EM structure of C-terminal arm of BIRC6 (from local refinement 4)
8E2F 2.47 Å, Cryo-EM structure of N-terminal arm of BIRC6 (from local refinement 2)
8E2G 2.99 Å, Cryo-EM structure of N-terminal arm (aa68-966) of BIRC6 (from local refinement 3)
8ATO 3.0 Å, Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC
8E2I 3.04 Å, Cryo-EM structure of BIRC6/Smac
9QH5 3.09 Å, Consensus structure of UBA6-UbDha-BIRC6 trapped ternary complex (doubly loaded)
8ATM 3.3 Å, Structure of the giant inhibitor of apoptosis, BIRC6 (composite map)
8ATU 3.3 Å, Cryo-EM structure of human BIRC6
9XGB 3.3 Å, UBA6-BIRC6 ubc-ubt

Browse structure collections

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