1LCY: Mitochondrial Serine Protease HtrA2

Crystal Structure of the Mitochondrial Serine Protease HtrA2. Determined by X-ray diffraction at 2.0 Å resolution. Released 22 May 2002.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,561
Mol. weight: 35 kDa
Released: 22 May 2002

Explore 1LCY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1LCY contains 12 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	10-13	4
α-helix	16-24	9
α-helix	25-27	3
β-strand	28-37	10	1
β-strand	42-55	14	1
β-strand	59-62	4	1
α-helix	64-67	4
β-strand	72-76	5	1
β-strand	82-91	10	1
β-strand	96-100	5	1
α-helix	106-108	3
β-strand	112	1	2
α-helix	115-117	3
α-helix	118-119	2
β-strand	123-126	4	2
β-strand	138-142	5	2
α-helix	161	1
β-strand	162-164	3	2
β-strand	176-179	4	2
β-strand	184-193	10	2
β-strand	196-201	6	2
α-helix	202-208	7
β-strand	227-228	2	3
β-strand	231-235	5	4
α-helix	238-244	7
β-strand	258-263	6	4
α-helix	268-272	5
β-strand	279-283	5	4
β-strand	286-287	2	4
α-helix	291-298	8
β-strand	304-310	7	4
β-strand	313-319	7	4
β-strand	322-323	2	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HtrA2 serine protease	A	protein	325	Homo sapiens	O43464 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1LCY_1 HtrA2 serine protease (chains A)
AVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLI
VTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQ
GEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNAGGPLVNL
DGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSI
LAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRT
QSQLAVQIRRGRETLTLYVTPEVTE

Primary citation

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Li, W., Srinivasula, S.M., Chai, J. et al. Nat Struct Biol (2002) 9:436-441. DOI 10.1038/nsb795 · PubMed

Other PDB entries of the same protein (UniProt O43464 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5M3N 1.65 Å, HTRA2 wild-type structure
5TO1 1.69 Å, HtrA2 exposed (L266R, F303A) mutant
5M3O 1.7 Å, HTRA2 A141S mutant structure
5TNY 1.7 Å, HTRA2 G399S mutant
5TNZ 1.75 Å, HtrA2 S142D mutant
5TO0 1.9 Å, HTRA2 S276C mutant
5FHT 1.95 Å, HtrA2 protease mutant V226K
5WYN 2.05 Å, HtrA2 Pathogenic Mutant
2PZD 2.75 Å, Crystal Structure of the HtrA2/Omi PDZ Domain Bound to a Phage-Derived Ligand (WTMFWV)
8E2K 3.21 Å, Cryo-EM structure of BIRC6/HtrA2-S306A
7VGE 4.0 Å, Structure of the PDZ deleted variant of HtrA2 protease (S306A)
8AUK 6.2 Å, Cryo-EM structure of human BIRC6 in complex with HTRA2.

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