Hypocretin neuropeptide precursor (HCRT) is a 131-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O43612.
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The mean pLDDT of this model is 60.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 78% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested
Rough endoplasmic reticulum, Cytoplasmic vesicle, Synapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1UVQ | X-ray | 1.8 Å | C=1-13 |
| 7L1U | EM | 3.2 Å | L=70-97 |
| 1CQ0 | NMR | A=71-97 | |
| 1R02 | NMR | A=34-66 | |
| 1WSO | NMR | A=34-66 |
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