5UJ7: Origin recognition complex subunit 1

Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5. Determined by X-ray diffraction at 3.39 Å resolution. Released 8 Feb 2017.

Method

X-ray diffraction

Resolution

3.39 Å

Organism

Homo sapiens

Chains

6

Atoms

15,870

Mol. weight

258.74 kDa

Ligands

ATP, MG

Released

8 Feb 2017

Explore 5UJ7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5UJ7 contains 116 α-helices and 48 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 21 helices, 8 β-strands

Molecules and chains

>5UJ7_1 Origin recognition complex subunit 1 (chains A, B)
APQIRSRSLAAQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCM
YISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQ
KATANHAAELLAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVL
AIANTMDLPERIMMNRVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVAR
KVAALSGDARRCLDICRRATEICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNS
SVLEQSFLRAILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCR
LLLVEPSRNDLLLRVRLNVSQDDVLYALKDE

>5UJ7_2 Origin recognition complex subunit 4 (chains C, D)
MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGES
NSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNL
ENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDIS
QSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEF
PDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAV
DLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRK
AHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPN
CPTDVRQWATSSLSWL

>5UJ7_3 Origin recognition complex subunit 5 (chains E, F)
MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVF
VNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTV
YIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFP
DYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPV
VKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKD

Ligands and cofactors

Water and common crystallization additives (K) are not listed.

Primary citation

Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Tocilj, A., On, K.F., Yuan, Z. et al. Elife (2017) 6. DOI 10.7554/eLife.20818 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q13415 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6P3W 2.54 Å, Crystal structure of the Cyclin A-CDK2-ORC1 complex
• 11RL 2.8 Å, CryoEM structure of the human origin recognition complex with DNA and CDC6 protein
• 7JPO 3.2 Å, ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH
• 8S0D 3.6 Å, H. sapiens MCM bound to double stranded DNA and ORC1-6
• 7JPP 3.7 Å, ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain
• 8S0E 3.8 Å, H. sapiens OCCM bound to double stranded DNA
• 7JPR 4.0 Å, ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation
• 8S0C 4.0 Å, H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex
• 8S0F 4.1 Å, H. sapiens OC1M bound to double stranded DNA
• 7JPS 4.4 Å, ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core
• 7CTF 4.8 Å, Human origin recognition complex 1-5 State II
• 7CTG 5.0 Å, Human Origin Recognition Complex, ORC1-5 State I

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