Rho guanine nucleotide exchange factor 7 (Arhgef7) is a 646-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O55043.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 72.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity)
Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis (By similarity). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and probably TGFB1I1. Interacts with ITCH and PARVB. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with PTK2/FAK1 and RAC1. Interacts with BIN2 (By similarity). Interacts with YWHAZ (By…
Cell junction, focal adhesion, Cell projection, ruffle, Cytoplasm, cell cortex, Cell projection, lamellipodium
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2G6F | X-ray | 0.92 Å | X=10-63 |
| 2DF6 | X-ray | 1.3 Å | A/B=10-63 |
| 2AK5 | X-ray | 1.85 Å | A/B=5-66 |
| 2P4R | X-ray | 2.0 Å | A=10-63 |
| 3QJN | X-ray | 2.71 Å | I/J/K/L/M/N/O/P=640-646 |
| 2W6B | X-ray | 2.8 Å | A=588-638 |
| 3L4F | X-ray | 2.8 Å | A/B/C=587-646 |
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