Glutamate transporter homolog (PH1295) is a 425-residue protein from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O59010.
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The mean pLDDT of this model is 91.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17230192, PubMed:17435767, PubMed:19380583, PubMed:20349989, PubMed:23563139, PubMed:25652997, PubMed:30255846, PubMed:33208356). Functions as a symporter that transports one aspartate molecule coupled to three Na(+) ions, resulting in electrogenic transport (PubMed:20349989, PubMed:23563139, PubMed:30255846, PubMed:33208356). Has only very low glutamate transport activity (PubMed:17230192, PubMed:19380583). In contrast to mammalian homologs, transport does not depend on H(+) or K(+) ions (PubMed:19380583). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, PubMed:25652997).…
Homotrimer
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RCP | EM | 2.2 Å | A/B/C=2-416 |
| 7AHK | X-ray | 2.5 Å | A=1-417 |
| 7UG0 | EM | 2.55 Å | A=1-418 |
| 9BH2 | EM | 2.7 Å | A=1-417 |
| 7UGJ | EM | 2.81 Å | A=1-418 |
| 7UGV | EM | 2.94 Å | A=1-418 |
| 7UGD | EM | 2.95 Å | A=1-418 |
| 2NWL | X-ray | 2.96 Å | A/B/C=1-417 |
| 7UGX | EM | 2.96 Å | A=1-418 |
| 7UH3 | EM | 2.99 Å | A=1-418 |
| 6X15 | EM | 3.05 Å | A/B/C=1-419 |
| 6UWF | EM | 3.08 Å | A=1-419 |
| 9BH1 | EM | 3.1 Å | A=1-417 |
| 2NWW | X-ray | 3.2 Å | A/B/C=1-417 |
| 4P19 | X-ray | 3.25 Å | A/B/C=1-417 |
| 2NWX | X-ray | 3.29 Å | A/B/C=1-417 |
| 9I6D | EM | 3.34 Å | A/B/C=1-425 |
| 6V8G | X-ray | 3.38 Å | A/B/C=1-419 |
| 6X16 | EM | 3.39 Å | A/B/C=1-419 |
| 6BAT | X-ray | 3.4 Å | A/B/C=1-417 |
Showing 20 of 47 experimental structures (best resolution first).
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