Crystal structure of the first bromodomain of human BRD4 in complex with SJ001010551-2. Determined by X-ray diffraction at 1.05 Å resolution. Released 3 Aug 2022.
Explore 7RN2 in 3D Show helices and sheets RCSB PDB PDBe
7RN2 contains 10 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 44-49 | 6 | |
| α-helix | 61-65 | 5 | |
| α-helix | 66-71 | 6 | |
| α-helix | 72-76 | 5 | |
| α-helix | 81-83 | 3 | |
| α-helix | 97-100 | 4 | |
| α-helix | 107-115 | 9 | |
| α-helix | 122-139 | 18 | |
| α-helix | 145-161 | 17 | |
| α-helix | 164-167 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | A | protein | 127 | Homo sapiens | O60885 (AlphaFold model) |
>7RN2_1 Bromodomain-containing protein 4 (chains A) SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE
| ID | Name | Formula | Copies |
|---|---|---|---|
| 5ZQ | 2-[(6S,10S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[… | C25 H23 Cl N6 O S | 1 |
Water and common crystallization additives (EDO) are not listed.
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Koravovic, M., Mayasundari, A., Tasic, G. et al. Eur J Med Chem (2023) 251:115246-115246. DOI 10.1016/j.ejmech.2023.115246 · PubMed
Other PDB entries of the same protein (UniProt O60885 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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