Autophagy-related protein 13 (ATG13) is a 517-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75143.
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The mean pLDDT of this model is 63.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation
Part of a complex consisting of ATG13, ULK1 and RB1CC1 (PubMed:19211835, PubMed:19225151, PubMed:19597335, PubMed:24290141). Interacts with ATG101 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Interacts with ULK1 (via C-terminus); this interaction is increased in the absence of TMEM39A (PubMed:18936157, PubMed:19287211, PubMed:21855797, PubMed:31806350). Interacts with ULK2 (via…
Cytoplasm, cytosol, Preautophagosomal structure
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HYN | X-ray | 1.14 Å | A=441-454 |
| 5C50 | X-ray | 1.63 Å | B=12-200 |
| 3WAN | X-ray | 1.77 Å | A/B=436-447 |
| 5XUY | X-ray | 2.2 Å | A/C=1-190 |
| 8DO8 | X-ray | 2.41 Å | B/D=1-197 |
| 5XV6 | X-ray | 2.46 Å | A=1-190 |
| 5XV1 | X-ray | 2.51 Å | A/C=1-190 |
| 5XV3 | X-ray | 2.57 Å | A/C=1-190 |
| 3WAO | X-ray | 2.6 Å | A/B/C/D=436-447 |
| 5XV4 | X-ray | 2.95 Å | A/C/E/G/I/K/M/O=1-190 |
| 3WAP | X-ray | 3.1 Å | A=436-447 |
| 8SOI | EM | 4.2 Å | D=462-517 |
| 8SRM | EM | 4.46 Å | E/F=450-517 |
| 8SQZ | EM | 5.85 Å | E/F=363-517 |
| 9C82 | EM | 6.84 Å | D=87-136 |
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