Pre-mRNA-processing factor 40 homolog A (PRPF40A) is a 957-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75400.
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The mean pLDDT of this model is 66.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing
Interacts with the N-terminus of HTT. Interacts with the phosphorylated C-terminal domain of POLR2A. Interacts with AKAP8L, SF1, SRPK1, ENAH, ATBF1 and MECP2 (By similarity). Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP (By similarity)
Nucleus speckle, Nucleus matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1UZC | NMR | A=381-450 | |
| 1YWI | NMR | A=142-173 | |
| 1YWJ | NMR | A=142-173 | |
| 1ZR7 | NMR | A=146-173 | |
| 2CQN | NMR | A=743-806 | |
| 2DYF | NMR | A=146-173 | |
| 2KZG | NMR | A=381-450 | |
| 2L5F | NMR | A=133-220 | |
| 2L9V | NMR | A=381-450 | |
| 2LKS | NMR | A=391-439 | |
| 8PXW | NMR | A=141-236 | |
| 8PXX | NMR | A=141-236 |
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