Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a 1119-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75762.
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The mean pLDDT of this model is 81.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 50% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants.…
Homotetramer (PubMed:25389312, PubMed:25855297, PubMed:31866091, PubMed:32641835). Interacts with TMEM100 (By similarity). Interacts with EGLN1 (By similarity). Interacts with the scorpion wasabi receptor toxin at the same site that electrophiles but in a non-covalent manner (PubMed:31447178)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HC8 | X-ray | 1.9 Å | E=313-339 |
| 6V9V | EM | 2.6 Å | A/B/C/D=1-1119 |
| 7OR0 | EM | 2.64 Å | A/B/C/D=1-1119 |
| 7OR1 | EM | 2.64 Å | A/B/C/D=1-1119 |
| 9MOE | EM | 2.7 Å | A/B/D/E=2-1119 |
| 6PQQ | EM | 2.81 Å | A/B/C/D=2-1119 |
| 6PQO | EM | 2.88 Å | A/B/C/D=2-1119 |
| 6X2J | EM | 3.0 Å | A/B/C/D=448-1078 |
| 7JUP | EM | 3.05 Å | A/B/C/D=448-1078 |
| 6PQP | EM | 3.06 Å | A/B/C/D=2-1119 |
| 6V9W | EM | 3.1 Å | A/B/C/D=1-1119 |
| 9M8S | EM | 3.1 Å | A/B/C/D=1-1119 |
| 6V9X | EM | 3.3 Å | A/B/C/D=1-1119 |
| 6V9Y | EM | 3.6 Å | A/B/C/D=1-1119 |
| 6WJ5 | EM | 3.6 Å | A/B/C/D=448-1078 |
| 9M8N | EM | 3.81 Å | A/B/C/D=1-1119 |
| 3J9P | EM | 4.24 Å | A/B/C/D=2-1119 |
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