Genome polyprotein is a 458-residue protein from Aichi virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: O91464.
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The mean pLDDT of this model is 95.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Inhibits the integrated stress response (ISR) in the infected cell by preventing the sequestration of eIF2B by phosphorylated EIF2S1/eIF-2alpha (PubMed:32690955). Stress granule formation in response to EIF2S1/eIF-2alpha phosphorylation is thus inhibited, which allows protein synthesis and viral replication (PubMed:32690955). Does not have any proteolytic activity (PubMed:14512530). Required for viral RNA replication and viral RNA encapsidation (PubMed:14512530)
Interacts with host eIF-2B; this interaction disrupts the interaction between eIF2 and eIF-2B, which leads to the inhibition of stress granules formation
Virion, Host cytoplasm, Host cytoplasmic vesicle membrane, Host Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7ZV1 | X-ray | 1.74 Å | A/B/C=1017-1152 |
| 5AOO | X-ray | 2.1 Å | A=764-1016, B=171-540, C=541-763 |
| 7ZV6 | X-ray | 2.83 Å | A/B/C=1017-1152 |
| 5LZ3 | X-ray | 3.0 Å | B=1653-1710 |
| 5GKA | EM | 3.7 Å | A=764-1016, B=174-540, C=541-762 |
| 5LVC | EM | 4.2 Å | a=764-1016, b=171-540, c=541-763 |
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