Serine/threonine-protein kinase PAK 4 (PAK4) is a 591-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O96013.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 70.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a…
Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1 (PubMed:15827085, PubMed:26598620). Interacts with INKA1 (PubMed:26607847). Interacts with SH3RF2 (PubMed:24130170). Interacts with RHOU and PAXI; the PAK4-RHOU complex protects RHOU from ubiquitination and acts as a scaffold to support paxillin/PAXI phosphorylation…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2J0I | X-ray | 1.6 Å | A=291-591 |
| 2Q0N | X-ray | 1.75 Å | A=291-591 |
| 5VEF | X-ray | 1.75 Å | A=286-591 |
| 5ZJW | X-ray | 1.8 Å | A=300-591 |
| 4JDI | X-ray | 1.85 Å | A=286-591 |
| 5XVA | X-ray | 1.85 Å | A=300-591 |
| 8AHG | X-ray | 1.89 Å | A=300-591 |
| 6WLY | X-ray | 1.9 Å | A=286-591 |
| 7S48 | X-ray | 1.9 Å | A=286-591 |
| 4FIH | X-ray | 1.97 Å | A=286-591 |
| 4FII | X-ray | 2.0 Å | A=286-591, B=49-56 |
| 4JDH | X-ray | 2.0 Å | A=286-591 |
| 7S47 | X-ray | 2.0 Å | A=286-591 |
| 8AHH | X-ray | 2.04 Å | A=300-591 |
| 4XBU | X-ray | 2.06 Å | A=286-591 |
| 2OV2 | X-ray | 2.1 Å | I/J/K/L/M/N/O/P=10-44 |
| 2X4Z | X-ray | 2.1 Å | A=296-591 |
| 5XVG | X-ray | 2.1 Å | A=300-591 |
| 7S46 | X-ray | 2.1 Å | A=286-591 |
| 4APP | X-ray | 2.2 Å | A=300-591 |
Showing 20 of 49 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.