L-lactate dehydrogenase A chain (LDHA) is a 332-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00338.
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The mean pLDDT of this model is 96.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)
Homotetramer (PubMed:11276087). Interacts with PTEN upstream reading frame protein MP31 (PubMed:33406399). Interacts with folliculin FLCN; the interaction is direct and inhibits enzymatic activity (PubMed:34381247)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5W8J | X-ray | 1.55 Å | A/B/C/D=1-332 |
| 5W8K | X-ray | 1.6 Å | A/B/C/D=1-332 |
| 5W8H | X-ray | 1.8 Å | A/B/C/D=1-332 |
| 9BK2 | X-ray | 1.85 Å | A/B/C/D=2-332 |
| 4JNK | X-ray | 1.9 Å | A/B/C/D=2-332 |
| 4RLS | X-ray | 1.91 Å | A/B/C/D=2-332 |
| 5W8I | X-ray | 1.95 Å | A/B/C/D=1-332 |
| 5W8L | X-ray | 1.95 Å | A/B/C/D=1-332 |
| 6BB0 | X-ray | 1.95 Å | A/B/C/D=2-332 |
| 6MV8 | X-ray | 1.95 Å | A/B/C/D=1-332 |
| 4QO8 | X-ray | 2.0 Å | A/B/C/D=2-332 |
| 6Q13 | X-ray | 2.0 Å | A/B/C/D=1-332 |
| 6MVA | X-ray | 2.02 Å | A/B/C/D=1-332 |
| 4M49 | X-ray | 2.05 Å | A/B/C/D=2-332 |
| 5IXS | X-ray | 2.05 Å | A/B/C/D=2-332 |
| 6BAX | X-ray | 2.05 Å | A/B/C/D=2-332 |
| 6Q0D | X-ray | 2.05 Å | A/B/C/D/E/F=1-332 |
| 4L4R | X-ray | 2.1 Å | A/H=2-332 |
| 4OKN | X-ray | 2.1 Å | A/B/C/D/E/F/G/H=2-332 |
| 6BAD | X-ray | 2.1 Å | A/B/C/D=2-332 |
Showing 20 of 46 experimental structures (best resolution first).
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