Deoxyribonuclease-1 (DNASE1) is a 282-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00639.
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The mean pLDDT of this model is 94.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 90% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2395459, PubMed:3352748, PubMed:4976790, PubMed:5166750). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular…
Secreted, Zymogen granule, Nucleus envelope
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2A40 | X-ray | 1.8 Å | B/E=23-282 |
| 3W3D | X-ray | 1.8 Å | B=23-282 |
| 2A42 | X-ray | 1.85 Å | B=23-282 |
| 2DNJ | X-ray | 2.0 Å | A=23-282 |
| 3DNI | X-ray | 2.0 Å | A=23-282 |
| 2A3Z | X-ray | 2.08 Å | B=23-282 |
| 1DNK | X-ray | 2.3 Å | A=23-282 |
| 2D1K | X-ray | 2.5 Å | B=23-282 |
| 7NXV | X-ray | 2.55 Å | B/F=23-282 |
| 2A41 | X-ray | 2.6 Å | B=23-282 |
| 1ATN | X-ray | 2.8 Å | D=23-282 |
| 9NB9 | EM | 3.03 Å | E=1-282 |
| 9FJY | EM | 3.79 Å | E/F=1-282 |
| 9FJU | EM | 3.84 Å | E/F=1-282 |
| 3CJC | X-ray | 3.9 Å | D=23-282 |
| 7NZM | EM | 3.96 Å | D=23-282 |
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