Metalloproteinase inhibitor 1 (TIMP1) is a 207-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01033.
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The mean pLDDT of this model is 89.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors
Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3V96 | X-ray | 1.9 Å | A=24-207 |
| 9SOP | X-ray | 1.95 Å | A/B=24-203 |
| 9SOS | X-ray | 2.0 Å | A=24-207 |
| 3MA2 | X-ray | 2.05 Å | B/C=24-148 |
| 9SOQ | X-ray | 2.3 Å | A/B=24-207 |
| 7S7L | X-ray | 2.34 Å | B=24-207 |
| 6MAV | X-ray | 2.37 Å | B=24-207 |
| 2J0T | X-ray | 2.54 Å | D/E/F=24-149 |
| 6N9D | X-ray | 2.67 Å | B=24-207 |
| 1UEA | X-ray | 2.8 Å | B/D=24-207 |
| 7S7M | X-ray | 3.0 Å | B=24-207 |
| 1D2B | NMR | A=24-149 | |
| 1OO9 | NMR | B=24-149 |
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