Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd). Determined by X-ray diffraction at 2.34 Å resolution. Released 16 Mar 2022.
Explore 7S7L in 3D Show helices and sheets RCSB PDB PDBe
7S7L contains 17 α-helices and 19 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 88-89 | 2 | |
| β-strand | 96-101 | 6 | 1 |
| α-helix | 110-125 | 16 | |
| β-strand | 131-134 | 4 | 1 |
| β-strand | 142-147 | 6 | 1 |
| β-strand | 162-167 | 6 | 1 |
| β-strand | 178-181 | 4 | 1 |
| β-strand | 186-187 | 2 | 2 |
| β-strand | 193-194 | 2 | 2 |
| α-helix | 195-207 | 13 | |
| β-strand | 222 | 1 | 1 |
| α-helix | 229-231 | 3 | |
| α-helix | 236-246 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-4 | 3 | 1 |
| α-helix | 5-7 | 3 | |
| α-helix | 8-14 | 7 | |
| β-strand | 17-30 | 14 | 3 |
| β-strand | 35-47 | 13 | 3 |
| α-helix | 49-51 | 3 | |
| β-strand | 60-64 | 5 | 3 |
| α-helix | 67-69 | 3 | |
| β-strand | 82-90 | 9 | 3 |
| β-strand | 93-95 | 3 | 3 |
| β-strand | 102-104 | 3 | 3 |
| α-helix | 105-107 | 3 | |
| α-helix | 110-114 | 5 | |
| α-helix | 115-119 | 5 | |
| α-helix | 120-123 | 4 | |
| β-strand | 128-131 | 4 | 4 |
| α-helix | 137-139 | 3 | |
| β-strand | 144-147 | 4 | 4 |
| α-helix | 150-152 | 3 | |
| α-helix | 155-157 | 3 | |
| α-helix | 159-163 | 5 | |
| β-strand | 164-170 | 7 | 5 |
| β-strand | 173-178 | 6 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Stromelysin-1 | A | protein | 173 | Homo sapiens | P08254 (AlphaFold model) |
| Metalloproteinase inhibitor 1 | B | protein | 184 | Homo sapiens | P01033 (AlphaFold model) |
>7S7L_1 Stromelysin-1 (chains A) FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADI MISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHE IGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET
>7S7L_2 Metalloproteinase inhibitor 1 (chains B) CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTGYQRYEIKMTKMYKGFQALGDAADIRF VYTPASYSVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTY TVGCEECTVFPCNSIPCKLQSGTHCLWTDQLLQGLEKGFQSRHLACLPREPGLCTWQSLR SQIA
Water and common crystallization additives (CL, TRS, SO4, ACT, GOL) are not listed.
Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. Raeeszadeh-Sarmazdeh, M., Coban, M., Mahajan, S. et al. J Biol Chem (2022) 298:101654-101654. DOI 10.1016/j.jbc.2022.101654 · PubMed
Other PDB entries of the same protein (UniProt P08254 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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