Kininogen-1 (KNG1) is a 644-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01042.
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The mean pLDDT of this model is 65.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting
Interacts (high molecular weight kininogen) (via amino acids 402-532) with triafestin-1 and triafestin-2, anticoagulant proteins from Triatoma infestans (PubMed:17645545). Interacts (high molecular weight kininogen) (via amino acids 402-532) with short form salivary protein D7R1, an anticoagulant protein from Anopheles stephensi (PubMed:17645545). Interacts (high molecular weight kininogen) (via…
Secreted, extracellular space
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2WOK | X-ray | 1.7 Å | B=381-389 |
| 4ASR | X-ray | 1.9 Å | P=381-389 |
| 4ASQ | X-ray | 1.99 Å | P=381-389 |
| 4ECB | X-ray | 2.2 Å | A/B=498-507 |
| 4ECC | X-ray | 2.2 Å | A=498-510 |
| 1NY2 | X-ray | 2.3 Å | 4=381-385 |
| 7QOX | X-ray | 2.32 Å | C/D=582-609 |
| 7F6I | EM | 2.8 Å | L=380-389 |
| 5I25 | X-ray | 2.85 Å | B=601-608 |
| 8VJX | X-ray | 2.89 Å | C=381-389 |
| 7F2O | EM | 2.9 Å | D=381-389 |
| 7F6H | EM | 2.9 Å | L=381-389 |
| 7EIB | EM | 3.0 Å | D=380-388 |
| 7QOT | X-ray | 3.24 Å | C/D=583-613 |
| 6F27 | NMR | A=380-388 | |
| 6F3V | NMR | A=381-389 | |
| 6F3W | NMR | A=381-389 | |
| 6F3X | NMR | A=380-388 | |
| 6F3Y | NMR | A=380-388 |
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