7F6I: Bradykinin receptor BK2R

Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin. Determined by electron microscopy at 2.8 Å resolution. Released 5 Jan 2022.

Method
Electron microscopy
Resolution
2.8 Å
Organism
Homo sapiens
Chains
5
Atoms
7,361
Mol. weight
180.68 kDa
Ligands
CLR
Released
5 Jan 2022

Explore 7F6I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7F6I contains 38 α-helices and 36 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix48-503
α-helix51-8434
α-helix88-892
α-helix91-10717
α-helix110-1189
α-helix126-15934
α-helix166-1683
α-helix171-18818
α-helix190-1945
β-strand196-20161
β-strand208-21361
α-helix218-2269
α-helix227-2348
α-helix235-25117
α-helix254-2563
α-helix265-29834
α-helix304-32017
α-helix323-3297
α-helix330-3345
α-helix337-35014
Chain B: 10 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix15-3521
α-helix36-383
β-strand39-4682
α-helix52-6211
β-strand190-19672
β-strand199-20572
α-helix213-2164
α-helix217-2204
β-strand225-23172
α-helix247-26014
α-helix262-2643
β-strand268-27472
α-helix277-2826
α-helix303-31412
β-strand324-32852
α-helix336-35520
Chain C: 5 helices, 28 β-strands
ElementResiduesLengthSheet
α-helix15-2410
α-helix30-334
α-helix34-363
β-strand47-5153
β-strand58-6364
β-strand69-7464
β-strand78-8364
β-strand88-9474
α-helix951
β-strand100-10565
β-strand111-11665
β-strand121-12555
β-strand134-13965
β-strand146-15386
β-strand156-16166
β-strand166-16836
β-strand178-18036
β-strand187-19267
β-strand198-20367
β-strand208-21257
β-strand218-22257
β-strand229-23468
β-strand240-24568
β-strand250-25458
β-strand260-26458
α-helix2721
β-strand273-27869
β-strand284-28969
β-strand294-29859
β-strand304-30859
β-strand315-32063
β-strand327-33153
β-strand336-33943
Chain D: 4 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix16-238
α-helix30-4415
α-helix45-473
α-helix53-553
Chain L: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix2-32

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Bradykinin receptor BK2RAprotein770Homo sapiensP30411 (AlphaFold model)
KallidinLprotein10Homo sapiensP01042 (AlphaFold model)
Guanine nucleotide-binding protein G(q) subunit alphaBprotein369Homo sapiensP50148 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Cprotein354Homo sapiensP62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Dprotein81Homo sapiensP59768
Sequence of entity 1 (A), FASTA
>7F6I_1 Bradykinin receptor BK2R (chains A)
MKTIIALSYIFCLVFADYKDDDDKHHHHHHHHHHENLYFQGKIEEGKLVIWINGDKGYNG
LAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEI
TPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKEL
KAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFV
GVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAA
TMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTLNVTLQGPTLNGT
FAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAA
ADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVK
TMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWE
VFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFII
CWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRK
KSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
Sequence of entity 2 (L), FASTA
>7F6I_2 Kallidin (chains L)
KRPPGFSPFR
Sequence of entity 3 (B), FASTA
>7F6I_3 Guanine nucleotide-binding protein G(q) subunit alpha (chains B)
MHHHHHHHHHHTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGES
GKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHA
QLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADP
AYLPTQQDVLRVQVPTTGIIEYPFDLQSVIFRMVDVGGLRSERRKWIHCFENVTSIMFLV
ALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVD
YFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQ
LNLKEYNLV
Sequence of entity 4 (C), FASTA
>7F6I_4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains C)
MHHHHHHHHHHGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMR
TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA
PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTC
ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE
SDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLL
AGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Sequence of entity 5 (D), FASTA
>7F6I_5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains D)
MHHHHHHHHHHASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPL
LTPVPASENPFREKKFFCAIL

Ligands and cofactors

IDNameFormulaCopies
CLRCholesterolC27 H46 O3

Primary citation

Cryo-EM structures of human bradykinin receptor-G q proteins complexes. Shen, J., Zhang, D., Fu, Y. et al. Nat Commun (2022) 13:714-714. DOI 10.1038/s41467-022-28399-1 · PubMed

Other PDB entries of the same protein (UniProt P30411 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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