Glycoprotein hormones alpha chain (CGA) is a 116-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01215.
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The mean pLDDT of this model is 91.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways
Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9YXD | X-ray | 2.29 Å | A=25-116 |
| 7UTZ | EM | 2.4 Å | A=25-116 |
| 4AY9 | X-ray | 2.5 Å | A/D/G=25-116 |
| 1HCN | X-ray | 2.6 Å | A=25-116 |
| 8I2G | EM | 2.8 Å | X=25-116 |
| 4MQW | X-ray | 2.9 Å | A/D/G=25-116 |
| 7T9I | EM | 2.9 Å | A=25-116 |
| 1XWD | X-ray | 2.92 Å | A/D=25-116 |
| 7XW5 | EM | 2.96 Å | X=25-116 |
| 1FL7 | X-ray | 3.0 Å | A/C=25-116 |
| 1HRP | X-ray | 3.0 Å | A=25-116 |
| 7FIH | EM | 3.2 Å | X=2-116 |
| 1QFW | X-ray | 3.5 Å | A=25-116 |
| 7FIG | EM | 3.9 Å | X=1-116 |
| 7FII | EM | 4.3 Å | X=1-116 |
| 1DZ7 | NMR | A=25-116 | |
| 1E9J | NMR | A=25-116 | |
| 1HD4 | NMR | A=25-116 |
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