Insulin-like growth factor 2 (IGF2) is a 180-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01344.
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The mean pLDDT of this model is 59.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 55% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates…
Interacts with MYORG; this interaction is required for IGF2 secretion (By similarity). Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling (PubMed:28873464). Interacts with IGFBP2 (PubMed:18563800)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3KR3 | X-ray | 2.2 Å | D=25-91 |
| 3E4Z | X-ray | 2.28 Å | C/D=25-91 |
| 6VWG | EM | 3.21 Å | I=25-91 |
| 8YSZ | EM | 3.38 Å | C/D=1-180 |
| 8U4C | EM | 3.6 Å | C/D/E/F=1-180 |
| 8VJB | EM | 3.6 Å | C/D/E/F=1-180 |
| 6VWI | EM | 3.7 Å | I=25-91 |
| 8VJC | EM | 3.8 Å | C/D/E=1-180 |
| 2V5P | X-ray | 4.1 Å | C/D=25-91 |
| 8U4E | EM | 4.2 Å | C/D/E=1-180 |
| 6UM2 | EM | 4.32 Å | B=25-91 |
| 1IGL | NMR | A=25-91 | |
| 2L29 | NMR | B=25-91 | |
| 5L3L | NMR | A=25-91 | |
| 5L3M | NMR | A=25-91 | |
| 5L3N | NMR | A=25-91 |
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