Coagulation factor XI (F11) is a 625-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P03951.
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The mean pLDDT of this model is 86.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX
Homodimer; disulfide-linked (PubMed:19548906, PubMed:22961984). Can form non-covalently bonded homodimers (PubMed:19548906). After activation the heavy and light chains are also linked by a disulfide bond (PubMed:22961984). Interacts (activated) with F9 (inactive and activated) in calcium-dependent manner (PubMed:22961984). Forms a heterodimer with SERPINA5 (PubMed:2844223). Interacts with…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MBO | X-ray | 0.92 Å | A=388-625 |
| 6TS4 | X-ray | 1.17 Å | A=388-625 |
| 4CRG | X-ray | 1.25 Å | A=388-625 |
| 8BO6 | X-ray | 1.25 Å | AAA=388-625 |
| 8BO7 | X-ray | 1.25 Å | AAA=388-625 |
| 6USY | X-ray | 1.26 Å | A=388-625 |
| 6TS5 | X-ray | 1.29 Å | A=388-625 |
| 6TS6 | X-ray | 1.33 Å | A=388-625 |
| 7V11 | X-ray | 1.47 Å | A=388-625 |
| 5EXN | X-ray | 1.49 Å | A=388-625 |
| 7V16 | X-ray | 1.5 Å | A=388-625 |
| 7V17 | X-ray | 1.52 Å | A=388-625 |
| 5TKS | X-ray | 1.55 Å | A=388-625 |
| 7V13 | X-ray | 1.59 Å | A=388-625 |
| 3BG8 | X-ray | 1.6 Å | A=388-625 |
| 4CRC | X-ray | 1.6 Å | A=388-625 |
| 6VLU | X-ray | 1.6 Å | A=388-625 |
| 4D7F | X-ray | 1.62 Å | A=388-625 |
| 7V12 | X-ray | 1.63 Å | A=388-625 |
| 7V15 | X-ray | 1.68 Å | A=388-625 |
Showing 20 of 114 experimental structures (best resolution first).
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