Protein Tat (tat) is a 86-residue protein from Human immunodeficiency virus type 1 group M subtype B. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P04608.
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The mean pLDDT of this model is 75.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Transcriptional activator that increases RNA Pol II processivity, thereby increasing the level of full-length viral transcripts. Recognizes a hairpin structure at the 5'-LTR of the nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR) and recruits the cyclin T1-CDK9 complex (P-TEFb complex) that will in turn hyperphosphorylate the RNA polymerase II to allow efficient elongation. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on…
Interacts with host CCNT1. Associates with the P-TEFb complex composed at least of Tat, P-TEFb (CDK9 and CCNT1), TAR RNA, RNA Pol II. Recruits the HATs CREBBP, TAF1/TFIID, EP300, PCAF and GCN5L2. Interacts with host KAT5/Tip60; this interaction targets the latter to degradation. Interacts with the host deacetylase SIRT1. Interacts with host capping enzyme RNGTT; this interaction stimulates…
Host nucleus, host nucleolus, Host cytoplasm, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MI9 | X-ray | 2.1 Å | C=1-86 |
| 5V61 | X-ray | 2.2 Å | I=49-57 |
| 4OR5 | X-ray | 2.9 Å | C/H=1-48 |
| 3MIA | X-ray | 3.0 Å | C=1-86 |
| 6CYT | X-ray | 3.5 Å | D=1-57 |
| 6MCE | NMR | B=44-60 | |
| 6MCF | NMR | B=44-60 |
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