Heterochromatin protein 1 (Su(var)205) is a 206-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05205.
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The mean pLDDT of this model is 76.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation (PubMed:26389589). Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11859155, PubMed:26389589). Stabilizes chromatin-associated RNAs probably by binding to them and thereby preventing their degradation (PubMed:26389589). Associates with, and may be a part of, the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion (PubMed:12510197, PubMed:20057353). Telomere capping is independent of…
Homodimer (PubMed:17875665). Probably associates with Su(var)3-9 (PubMed:17875665). Interacts with Mcm10 (PubMed:12808023). Interacts (via chromoshadow domain) with piwi (via N-terminal region) (PubMed:17875665). Interacts with Rrp6 (PubMed:26389589). Associates with and may be part of the HipHop-HOAP telomere capping complex but is not required for its stability or telomere localization…
Nucleus, Nucleus, nucleoplasm, Chromosome, Chromosome, telomere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6AT0 | X-ray | 1.28 Å | A=17-76 |
| 6MHA | X-ray | 1.5 Å | A=22-74 |
| 6ASZ | X-ray | 1.52 Å | A=17-76 |
| 1Q3L | X-ray | 1.64 Å | A=17-76 |
| 1KNA | X-ray | 2.1 Å | A=17-76 |
| 3P7J | X-ray | 2.3 Å | A/B=131-206 |
| 1KNE | X-ray | 2.4 Å | A=17-76 |
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