Complement C5 (C5) is a 1680-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06684.
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The mean pLDDT of this model is 81.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 61% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Activated downstream of classical, alternative, lectin and GZMK complement pathways
In absence of complement activation, the C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond
Secreted, Target cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4P3A | X-ray | 1.4 Å | A/B/C/D=679-755 |
| 4WB2 | X-ray | 1.8 Å | A/B/C=679-755 |
| 4WB3 | X-ray | 2.0 Å | A/B/C=679-754 |
| 4P3B | X-ray | 2.1 Å | A/B/C/D=679-754 |
| 9KWX | EM | 3.13 Å | F=679-754 |
| 9KWG | EM | 3.15 Å | F=679-755 |
| 8JZP | EM | 3.45 Å | F=679-755 |
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