Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S) is a 1873-residue protein from Oryctolagus cuniculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07293.
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The mean pLDDT of this model is 71.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163, PubMed:9465115). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:15201141, PubMed:27621462, PubMed:9465115). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:15134636, PubMed:25667046, PubMed:26680202, PubMed:27580036, PubMed:27621462, PubMed:3037387). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2…
Cell membrane, sarcolemma, T-tubule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RXQ | X-ray | 2.03 Å | B=1594-1609 |
| 1T3L | X-ray | 2.2 Å | B=357-374 |
| 6JPA | EM | 2.6 Å | A=1-1506 |
| 6JP8 | EM | 2.7 Å | A=1-1873 |
| 8E56 | EM | 2.8 Å | A=1-1873 |
| 8E57 | EM | 2.8 Å | A=1-1873 |
| 6JP5 | EM | 2.9 Å | A=1-1873 |
| 6JPB | EM | 2.9 Å | A=1-1873 |
| 7JPX | EM | 2.9 Å | A=1-1873 |
| 7JPK | EM | 3.0 Å | A=1-1873 |
| 8E58 | EM | 3.0 Å | A=1-1873 |
| 7JPW | EM | 3.2 Å | A=1-1873 |
| 7JPL | EM | 3.4 Å | A=1-1873 |
| 7JPV | EM | 3.4 Å | A=1-1873 |
| 5GJV | EM | 3.6 Å | A=1-1873 |
| 6BYO | EM | 3.6 Å | A=32-1388 |
| 5GJW | EM | 3.9 Å | A=1-1873 |
| 3JBR | EM | 4.2 Å | A=1-1873 |
| 1DU1 | NMR | A=671-690 | |
| 1JZP | NMR | A=671-690 |
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