Histone H1.0 (H1-0) is a 194-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07305.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 68.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 36% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161). The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (PubMed:7374750)
Associates with nucleosomes, promoting condensation into higher-order structured chromatin
Nucleus, Nucleus, nucleolus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7COW | X-ray | 2.86 Å | S/T=2-194 |
| 7K5X | EM | 2.93 Å | U=1-194 |
| 6LAB | X-ray | 3.2 Å | U/V=1-194 |
| 7XX6 | X-ray | 3.39 Å | o/p=2-194 |
| 6LA8 | X-ray | 3.4 Å | S=1-194 |
| 7XVL | X-ray | 3.51 Å | o=2-194 |
| 6LA9 | X-ray | 3.7 Å | S/T=1-194 |
| 6LA2 | X-ray | 3.89 Å | S/T=1-194 |
| 8TB9 | EM | 4.0 Å | A=1-194 |
| 9IPU | EM | 4.3 Å | I=1-194 |
| 7DBP | EM | 4.5 Å | K=2-194 |
| 6N88 | EM | 6.2 Å | C=1-194 |
| 9QEJ | EM | 6.2 Å | C=1-194 |
| 6N89 | EM | 7.5 Å | B=1-194 |
| 9QF0 | EM | 7.5 Å | C=1-194 |
| 6HQ1 | NMR | A=24-97 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.