9QF0: Mportin7:Histone H1.0 complex

Cryo-EM structure of the mportin7:Histone H1.0 complex. Determined by electron microscopy at 7.5 Å resolution. Released 14 Jan 2026.

Method
Electron microscopy
Resolution
7.5 Å
Organisms
Xenopus laevis, Homo sapiens
Chains
2
Atoms
9,196
Mol. weight
140.48 kDa
Released
14 Jan 2026

Explore 9QF0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9QF0 contains 77 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 71 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix3-86
α-helix10-145
α-helix16-2712
α-helix35-4410
α-helix50-6213
α-helix63-675
α-helix85-10117
α-helix104-11714
α-helix118-1203
α-helix126-13510
α-helix136-1383
α-helix145-1495
α-helix150-1534
α-helix157-1604
α-helix164-1663
α-helix168-1758
α-helix178-18710
α-helix194-21118
α-helix222-23716
α-helix243-2464
α-helix252-2543
α-helix258-27417
α-helix283-2853
α-helix288-2925
α-helix296-31217
α-helix316-3183
α-helix319-33214
α-helix336-3416
α-helix343-3453
α-helix346-3549
α-helix362-3632
α-helix364-3685
α-helix369-3702
α-helix372-3776
α-helix390-40314
α-helix407-41913
α-helix426-43813
α-helix440-4434
α-helix452-46615
α-helix470-48314
α-helix491-50717
α-helix511-52414
α-helix525-5273
α-helix531-5333
α-helix536-55015
α-helix556-56611
α-helix574-59219
α-helix602-62120
α-helix626-64520
α-helix649-6513
α-helix653-66210
α-helix670-6734
α-helix675-68410
α-helix690-6934
α-helix694-70310
α-helix705-7095
α-helix715-72612
α-helix732-74716
α-helix755-7573
α-helix759-7657
α-helix766-7683
α-helix776-79217
α-helix794-80310
α-helix813-82412
α-helix831-84616
α-helix854-88330
α-helix912-92110
α-helix958-96710
α-helix968-9725
α-helix974-9807
α-helix986-101227
Chain C: 6 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix28-369
α-helix47-5711
α-helix62-654
α-helix68-725
α-helix74-774
β-strand81-8331
β-strand93-9531
α-helix107-11812

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin 7 L homeologAprotein1038Xenopus laevisO42480 (AlphaFold model)
Histone H1.0Cprotein194Homo sapiensP07305 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9QF0_1 Importin 7 L homeolog (chains A)
MDPNILIEALRGTMDPALREAAERQLNESHKSLHFVSTLLQITMSEQLELPVRQAGVIYL
KNMITQYWPDREVTPGELPPHTIPEEDRHCIRENIVEAIMHSPELIRVQLTTCIHHIIKH
DYPNRWTAVVEKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLIAAMQHFLPM
LKDRYIQLLADPSEQSVLIQKQIFKIFYALVQYTLPLELINQQNLAEWIEILKTVVDRDV
PAETLQVDEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNDFAEVFLKAFAVGV
QQVLLKVLYQYKEKQYIAPRVLQQTLNYFNQGVSHAVTWKNLKPHIQGIIQDVIFPLMCY
TDSDEDLWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTSCSKRKEVLQKTMGFCYQILT
EPAADPRKKDGALHMIGSLAEILLKKKIYKDQMEFMLQNHVFPLFSSELGYMRARACWVL
HYFCEVKFKVDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYIVPFIR
PVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEG
SDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAH
SLTCQQVSPQMWQLLPLVFDIFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYS
MCKKILTGVAGEDAECHAAKLLEVVILQCKGRGIDQVIPLFVEAALERLTREVKTSELRT
MCLQVAIAALYYSPPLLFNTLENLRFPNNEEPVTNHFIKQWLNDVDCFLGLHDRKICVLG
LCALIELEQRPQVLNQMSSQILPAFLLLFNGLKRAYACHAEQENDSDDDGDGEDDEDAAE
LGSDEDDIDEEGQEYLEILAKQAGEDGDDEDWEDDDAEETALEGYTTLLDDEDTPIDEYQ
IFKAIFQKLQGRDPVWYQALTQGLNEDQGKQLQDIATLADQRRAAHESKMIEKHGGYKFN
APVVPSTFNFGNPAPGMN
Sequence of entity 2 (C), FASTA
>9QF0_2 Histone H1.0 (chains C)
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKV
GENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATP
KKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVK
PKAKSSAKRAGKKK

Primary citation

Alphafold 3-guided insights into the Importin beta : Importin7 heterodimer interaction and its binding to histone H1. Neumann, P., Dybkov, O., Urlaub, H. et al. Structure (2026) 34:414-425.e4. DOI 10.1016/j.str.2025.12.011 · PubMed

Other PDB entries of the same protein (UniProt O42480 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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