9QEJ: Importin beta:Importin7:Histone H1.0 complex

Cryo-EM structure of the Importin beta:Importin7:Histone H1.0 complex. Determined by electron microscopy at 6.2 Å resolution. Released 14 Jan 2026.

Method
Electron microscopy
Resolution
6.2 Å
Organisms
Xenopus laevis, Homo sapiens
Chains
3
Atoms
14,719
Mol. weight
237.74 kDa
Released
14 Jan 2026

Explore 9QEJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9QEJ contains 120 α-helices and 3 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 70 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix3-97
α-helix16-2712
α-helix35-428
α-helix50-6617
α-helix85-939
α-helix95-1017
α-helix104-11916
α-helix128-1369
α-helix142-16019
α-helix164-1674
α-helix168-1703
α-helix171-1744
α-helix178-18811
α-helix194-21118
α-helix222-23716
α-helix243-2464
α-helix252-2543
α-helix256-27015
α-helix271-2766
α-helix283-2853
α-helix286-2916
α-helix292-2943
α-helix296-31318
α-helix319-33214
α-helix336-3416
α-helix343-3453
α-helix346-3505
α-helix362-3709
α-helix372-3798
α-helix389-40315
α-helix408-4158
α-helix416-4205
α-helix426-43813
α-helix440-4434
α-helix447-4493
α-helix452-46110
α-helix462-4665
α-helix470-48213
α-helix492-50716
α-helix511-52515
α-helix530-5334
α-helix536-5383
α-helix539-55315
α-helix556-56611
α-helix570-5734
α-helix577-59317
α-helix601-62020
α-helix627-64418
α-helix653-66210
α-helix670-6734
α-helix675-68410
α-helix693-7019
α-helix713-72715
α-helix732-74817
α-helix758-7625
α-helix763-7675
α-helix772-7732
α-helix776-79015
α-helix794-80310
α-helix813-82412
α-helix825-8273
α-helix831-84414
α-helix852-8543
α-helix861-88323
α-helix889-8913
α-helix912-92312
α-helix929-9313
α-helix959-97113
α-helix974-9807
α-helix986-101328
Chain B: 43 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix167-18115
α-helix188-20114
α-helix207-2104
α-helix213-22513
α-helix231-24717
α-helix251-2544
α-helix256-2605
α-helix261-2699
α-helix273-29927
α-helix300-3045
α-helix315-32612
α-helix346-35914
α-helix364-37613
α-helix380-39314
α-helix399-41820
α-helix422-43817
α-helix449-46214
α-helix464-4663
α-helix467-48822
α-helix500-51516
α-helix517-5204
α-helix526-5349
α-helix541-5433
α-helix544-56421
α-helix571-59121
α-helix598-61720
α-helix623-63917
α-helix644-6507
α-helix651-6533
α-helix654-6585
α-helix664-68017
α-helix686-6883
α-helix689-69810
α-helix709-72416
α-helix729-7313
α-helix732-74413
α-helix752-77726
α-helix785-7939
α-helix794-80512
α-helix813-82614
α-helix832-8387
α-helix841-85111
α-helix856-87318
Chain C: 7 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix28-369
α-helix441
β-strand4511
α-helix47-5711
α-helix62-643
α-helix65-7814
β-strand81-8331
β-strand93-9531
α-helix101-1022
α-helix107-11711

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin 7 L homeologAprotein1038Xenopus laevisO42480 (AlphaFold model)
Importin subunit beta-1Bprotein876Homo sapiensQ14974 (AlphaFold model)
Histone H1.0Cprotein194Homo sapiensP07305 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9QEJ_1 Importin 7 L homeolog (chains A)
MDPNILIEALRGTMDPALREAAERQLNESHKSLHFVSTLLQITMSEQLELPVRQAGVIYL
KNMITQYWPDREVTPGELPPHTIPEEDRHCIRENIVEAIMHSPELIRVQLTTCIHHIIKH
DYPNRWTAVVEKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLIAAMQHFLPM
LKDRYIQLLADPSEQSVLIQKQIFKIFYALVQYTLPLELINQQNLAEWIEILKTVVDRDV
PAETLQVDEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNDFAEVFLKAFAVGV
QQVLLKVLYQYKEKQYIAPRVLQQTLNYFNQGVSHAVTWKNLKPHIQGIIQDVIFPLMCY
TDSDEDLWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTSCSKRKEVLQKTMGFCYQILT
EPAADPRKKDGALHMIGSLAEILLKKKIYKDQMEFMLQNHVFPLFSSELGYMRARACWVL
HYFCEVKFKVDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYIVPFIR
PVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEG
SDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAH
SLTCQQVSPQMWQLLPLVFDIFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYS
MCKKILTGVAGEDAECHAAKLLEVVILQCKGRGIDQVIPLFVEAALERLTREVKTSELRT
MCLQVAIAALYYSPPLLFNTLENLRFPNNEEPVTNHFIKQWLNDVDCFLGLHDRKICVLG
LCALIELEQRPQVLNQMSSQILPAFLLLFNGLKRAYACHAEQENDSDDDGDGEDDEDAAE
LGSDEDDIDEEGQEYLEILAKQAGEDGDDEDWEDDDAEETALEGYTTLLDDEDTPIDEYQ
IFKAIFQKLQGRDPVWYQALTQGLNEDQGKQLQDIATLADQRRAAHESKMIEKHGGYKFN
APVVPSTFNFGNPAPGMN
Sequence of entity 2 (B), FASTA
>9QEJ_2 Importin subunit beta-1 (chains B)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence of entity 3 (C), FASTA
>9QEJ_3 Histone H1.0 (chains C)
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKV
GENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATP
KKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVK
PKAKSSAKRAGKKK

Primary citation

Alphafold 3-guided insights into the Importin beta : Importin7 heterodimer interaction and its binding to histone H1. Neumann, P., Dybkov, O., Urlaub, H. et al. Structure (2026) 34:414-425.e4. DOI 10.1016/j.str.2025.12.011 · PubMed

Other PDB entries of the same protein (UniProt O42480 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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