Tubulin beta chain (TUBB) is a 444-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07437.
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The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Heterodimer of alpha and beta chains (PubMed:26637975). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules…
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3QNZ | X-ray | 2.2 Å | C=429-438 |
| 3QO0 | X-ray | 2.3 Å | C=422-441 |
| 8BPO | EM | 2.8 Å | u2=1-60 |
| 7TTT | EM | 2.9 Å | A=1-444 |
| 8V2J | EM | 2.9 Å | B/E=1-444 |
| 9COC | EM | 2.9 Å | B/E/F/K=1-444 |
| 7TRG | EM | 3.0 Å | A=1-444 |
| 7X0S | EM | 3.1 Å | R=1-444 |
| 9BP6 | EM | 3.1 Å | B/Q=1-444 |
| 9CMM | EM | 3.1 Å | B/D/F/Q=1-444 |
| 9HQ4 | EM | 3.28 Å | B/D=1-444 |
| 7TTN | EM | 3.3 Å | A=1-444 |
| 6I2I | EM | 3.6 Å | B=1-444 |
| 7TUB | EM | 3.6 Å | A=1-444 |
| 8T42 | EM | 3.6 Å | B/E=1-444 |
| 8U3Z | EM | 3.6 Å | B/E=1-444 |
| 6QUS | EM | 3.7 Å | S/U=1-444 |
| 6QVE | EM | 3.7 Å | G/H=1-444 |
| 6QUY | EM | 3.8 Å | G/H=1-444 |
| 6QVJ | EM | 3.8 Å | S/U=1-444 |
Showing 20 of 21 experimental structures (best resolution first).
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