Amino acid transporter heavy chain SLC3A2 (SLC3A2) is a 630-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08195.
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The mean pLDDT of this model is 78.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. Forms heterodimers with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049, PubMed:37918808). Heterodimers function as amino acid exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer…
Disulfide-linked heterodimer with a non-glycosylated catalytic light subunit (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 or SLC7A11) (PubMed:10574970, PubMed:10903140, PubMed:11311135, PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:35352032, PubMed:9751058, PubMed:9829974, PubMed:37918808). Interacts…
Apical cell membrane, Cell membrane, Cell junction, Lysosome membrane, Melanosome, Basolateral cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6S8V | X-ray | 1.8 Å | B/D=111-529 |
| 2DH2 | X-ray | 2.1 Å | A=111-529 |
| 8G0M | X-ray | 2.25 Å | A=111-529 |
| 9KJU | EM | 2.7 Å | A=1-529 |
| 2DH3 | X-ray | 2.8 Å | A/B=111-529 |
| 7DF1 | X-ray | 2.81 Å | A/B/C/D=111-529 |
| 7CMI | EM | 2.9 Å | A=1-529 |
| 7DSK | EM | 2.9 Å | A=1-529 |
| 7DSL | EM | 2.9 Å | A=1-529 |
| 8YLP | EM | 2.9 Å | A=1-529 |
| 7DSN | EM | 3.1 Å | A=1-529 |
| 8X0W | EM | 3.1 Å | A=60-529 |
| 8A6L | EM | 3.18 Å | A=1-529 |
| 8IDA | EM | 3.2 Å | A=1-529 |
| 6IRS | EM | 3.3 Å | A=1-529 |
| 8XPU | EM | 3.3 Å | A=1-529 |
| 6JMQ | EM | 3.31 Å | B=1-529 |
| 7CMH | EM | 3.4 Å | A=1-529 |
| 7DSQ | EM | 3.4 Å | A=1-529 |
| 7EPZ | EM | 3.4 Å | A=1-529 |
Showing 20 of 43 experimental structures (best resolution first).
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