ATP-dependent RNA helicase vasa (vas) is a 661-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P09052.
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The mean pLDDT of this model is 72.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells. May have a role in production of piwi-interacting RNA (piRNA) (PubMed:17428915)
Interacts with eIF5B and faf. Interacts with gus (via B30.2/SPRY domain) and Fsn (via B30.2/SPRY domain). Interacts with aub, me31B, eIF-4a and TER94. Interacts with piwi; this interaction is RNA independent. Interacts with Dcr-1 and Fmr1; these interactions occur in the polar granules
Cytoplasm, Cytoplasm, perinuclear region, Cytoplasm, Cytoplasmic ribonucleoprotein granule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NT7 | X-ray | 1.4 Å | B/D=463-623 |
| 3EMW | X-ray | 1.8 Å | B=184-203 |
| 3F2O | X-ray | 2.05 Å | C/D=184-203 |
| 2DB3 | X-ray | 2.2 Å | A/B/C/D=200-623 |
| 2IHS | X-ray | 2.2 Å | C/D=184-203 |
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